The integrin α4β7 selectively regulates lymphocyte trafficking and adhesion in the gut gut-associated lymphoid tissues (GALT). Here we describe unexpected involvement of tyrosine phosphatase Shp1 B cell lectin CD22 (Siglec 2) regulation surface expression immunity. inhibited β7 endocytosis, enhancing display homing to GALT. In cells, associated a sialic acid-dependent manner with on target intr...

ABSTRACT Most of plasma membrane transporters are downregulated by ubiquitination-dependent endocytosis to avoid the excess uptake their substrates. In Saccharomyces cerevisiae, ubiquitination is mediated HECT-type ubiquitin ligase Rsp5. We report here a mechanism underlying substrate-induced broad-specificity amino acid permease Agp1. First, we found that Agp1 underwent and in response additio...

Neonatal RBCs can undergo receptor-mediated endocytosis; normal adult RBCs cannot. Previously, we showed that drug-induced endocytosis, which can occur in adult RBCs exposed to amphipathic cations like primaquine, is greatly enhanced in all density-defined fractions of neonatal RBCs. To investigate the similarities and differences between receptor-mediated endocytosis and drug-induced endocytos...

Steady-state surface levels of the apical Na/K/2Cl cotransporter NKCC2 regulate NaCl reabsorption by epithelial cells of the renal thick ascending limb (THAL). We reported that constitutive endocytosis of NKCC2 controls NaCl absorption in native THALs; however, the pathways involved in NKCC2 endocytosis are unknown. We hypothesized that NKCC2 endocytosis at the apical surface depends on dynamin...