5. Mallett SV, RoUes K, Cox D, Burroughs A, Hunt B. Intraopcrative use of aprotinin (Trasylol) in orthotopic liver transplantation. Transplantation Proceedings 1991; 23: 19311932. 6. Thomson JF, Roath OS, Francis JL, Webster JHM, Chant ADB. Aprotinin in peripheral vascular surgery. Lancet 1990; 335:911. 7. Kobrinsky NL, Letts MR, Patcl LR, l-Desamino-8-D arginine vasopressine (Desmopressin) dec...

To the Editor Mardani-Kivi et al presented results about a triple blinded randomized controlled trial with gabapentin in patients that underwent anterior cruciate ligament (ACL) reconstruction (1). In their manuscript, the introduction section is very illustrative about the subject. With respect to methodology, it is well known that the physical diagnosis of ACL injury is particularly difficult...

BACKGROUND Experimental studies suggest pre-emptive administration of analgesics is effective but clinical evidence is less convincing. METHODS Forty-one patients undergoing abdominal hysterectomy were allocated randomly in a double-blind fashion to receive sufentanil 50 micrograms via a lumbar epidural catheter before or at the end of surgery. RESULTS Sufentanil consumption from a patient-...

Our knowledge and understanding of the physiology of acute pain has improved in recent years. Most of this new information has been gathered from basic science and experimental studies. The recent papers by Wall [40] and Woolf [41] have stimulated much discussion on the potential clinical implications of this knowledge for the management of acute postoperative pain, and the concept of "pre-empt...

BACKGROUND Although pre-emptive analgesia is commonly used for the management of postoperative pain in developed countries, no defined protocol has been carried out and widely practiced, especially in transabdominal hysterectomy. Keeping this in mind the present study aimed to investigate the effects of multimodal pre-emptive analgesia on pain management, stress response and inflammatory factor...

It has been suggested that there may be some advantage in pre-emptive administration of analgesics, which may be of some relevance in day-surgery. Post-operative pain control is often difficult due to the reluctance to use potent analgesics, whose side effects include nausea and vomiting, which are an important cause of delayed discharge. In order to test the potential beneficial effects of pre...

 ABSTRACT Background: Postoperative pain is an important surgical problem. Recent studies in pain pathophysiology have led to the hypothesis that with perioperative administration of analgesics (pre-emptive analgesia) it may be possible to prevent or reduce postoperative pain. This study was planned to investigate the efficacy of pre-emptive analgesia on postoperative pain after major gynecolog...

AIM Vitrectomies are performed either under general anesthesia (GA), local anesthesia (LA), or a combination of both. Postoperative pain is expected to be less in patients with LA because of prolonged action of the local anaesthetic. Pre-emptive analgesia is based on the idea that analgesia initiated before a nociceptive event will be more effective than analgesia commenced afterwards. The auth...