Emerging Therapies: ESPRIT To the Editor: It was with great anticipation and interest that I read the ESPRIT results1 and the accompanying Editorial in Stroke.2 The study reports superiority of aspirin plus dipyridamole over aspirin alone in patients with minor or transient cerebral ischemic symptoms, for the composite outcome of vascular mortality, cerebrovascular event, myocardial infarction,...

In the United States alone, about 250,000 people develop significant mitral regurgitation (MR) each year, with almost 50,000 undergoing surgery. Surgical repair of a diseased mitral valve has become the treatment of choice for patients with significant MR. Since there is no single therapeutic approach for every etiology of MR, surgical mitral valve repair includes a variety of techniques that a...

It is likely that all new therapeutic interventions will be used with methotrexate in combination therapy. These combinations may yield real therapeutic advances. The potential for end organ toxicity, opportunistic infection, and malignancy will need to be carefully monitored with long-term, meticulously conducted observational studies. Expense, ease of use, and perceived benefit-to-risk ratio ...

Although several effective therapies are available for the treatment of osteoporosis in postmenopausal women and older men, there remains a need for the development of even more effective and acceptable drugs. Several new drugs that are in late-stage clinical development will be discussed. Abaloparatide (recombinant parathyroid hormone related peptide [PTHrP] analogue) has anabolic activity lik...