Background and Objective: Electroconvulsive therapy (ECT) is the end choice treatment for patients with major depressive disorder (MDD). Regarding researches that show NMDA receptor inactivation could yield the same results as anti-depressant drugs, however, the present study examined co-administration of ECT and ketamine (as NMDA antagonist) on depressed rat behaviors.   Materials and Methods...

Background and Objective: Electroconvulsive therapy (ECT) is one of the effective and less complicated methods for treatment of depression in cases of resistance to common treatments. Given the fundamental role of pre-frontal cortex on changing the mood of depression-related behaviors in depressed patients, the effects of electroconvulsive therapy on enzymatic activity of this cortex were taken...

Electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD). Biomarkers predicting individuals’ response to ECT would provide more successful and personalized treatment strategies. This study aimed investigate whether dynamic functional connectivity (dFC) estimated from resting-state fMRI (rs-fMRI) predicts outcome.

Electroconvulsive therapy (ECT) is the most effective treatment for severe major depressive episodes (MDE). Nonetheless, firmly established associations between ECT outcomes and biological variables are currently lacking. Polygenic risk scores (PRSs) carry clinical potential but with response in psychiatry seldom reported. Here, we examined whether PRSs disorder, schizophrenia, cross-disorder, ...

AIMS AND OBJECTIVES The use of electroconvulsive therapy (ECT) in children and adolescents is a controversial issue. This study was done to examine the pattern and practice as well as the outcome of electroconvulsive therapy administered to children and adolescents admitted to a tertiary care centre. METHODOLOGY A 10 year retrospective chart review of all children and adolescents (up to 16 ye...

Patients with somatoform disorders can be significantly impacted by the condition and there is often comorbid depression anxiety. In cases that are treatment resistant, disorder persisting despite intensive psychological input numerous psychotropic medications, use of electroconvulsive therapy (ECT) has been considered a possible option. Here, authors report case such patient who responded to E...

The aim of this study was to determine the characteristics of ECT practice in Polish Psychiatric Clinics in 2005. A questionnaire was sent to all Polish psychiatric hospitals that performed electroconvulsive therapy in 2005. Altogether 450 patients (0.22% of the general number of psychiatric inpatients in 2005 and 0.72% of the inpatients of hospitals where electroconvulsive therapy was performe...

The perceptions of patients and their family members about electroconvulsive therapy (ECT) are crucial to understanding the meaning attached to having ECT and the impact it has on quality of life. Thus, in this qualitative study, patients and their family members described their perceptions of having electroconvulsive therapy (ECT). The experience occurred in two distinct periods in the patient...

This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experi...

Electroconvulsive therapy (ECT) offers a treatment option for mood disorders during pregnancy. We retrospectively examined 12 pregnant patients who were treated with ECT for their mood disorders. The mean ± SD age of the patients was 28.1 ± 4.8 years. The mean ± SD number of ECTs performed was 9.8 ± 4.5. The mean ± SD Clinical Global Impression score was decreased from 6 to 2.6 ± 0.7 with ECT. ...