An alkylating camptothecin (CPT) derivative, 7-chloromethyl-10,11-methylenedioxy-camptothecin (7-CM-MDO-CPT) was recently shown to produce irreversible topoisomerase I (top1) cleavage complexes by binding to the +1 base of the scissile strand of a top1 cleavage site. We demonstrate that 7-CM-EDO-CPT (7-chloromethyl-10,11-ethylenedioxy-camptothecin) also induces irreversible top1-DNA complexes. ...

Chronic pelvic pain syndrome (CPPS) is the most prevalent form of prostatitis. It is characterized by pelvic pain, voiding symptoms, and ejaculatory symptoms in the absence of bacterial infection. This can be a difficult condition to treat. Many etiologies for CPPS have been proposed including immunologic, neurologic, endocrine, and psychological factors. This article examines a potentially cor...

PURPOSE Various diagnostic tests are available to evaluate patients with ejaculatory duct obstruction (EDO). However, the most accurate diagnostic technique, defined as the one that best predicts a successful outcome after ejaculatory duct resection, is unclear. We prospectively performed transrectal ultrasound (TRUS) and 3 other tests in men with EDO and determined their relative value in this...

Evolutionary dynamic optimisation (EDO), or the study of applying evolutionary algorithms to dynamic optimisation problems (DOPs) is the focus of this thesis. Based on two comprehensive literature reviews on existing academic EDO research and realworld DOPs, this thesis for the first time identifies some important gaps in current academic research where some common types of problems and problem...

Indiana University turned into a hot spot for the research of sexuality in Edo culblre when it hosted the international conference. "Sexuality and Edo Culture. 17S0-1850" from August 17 to 20. 1995. As the organizer. Sumie Jones. mentioned in her opening remarks, sexuality in Edo cUlnare has been largely ignored by ~~cs in d)e U.S. and. to an even greater extent, Japan. The conference was desig...

Uni- or bilateral ejaculatory duct obstruction (EDO) is a rare but correctable cause of infertility, chronic pelvic pain and postejaculatory pain. EDO is a congenital or acquired condition, it is the underlying cause of infertility in approximately 5% of infertile men. If acquired, the etiology often remains unresolved, but prostatitis or urethritis with post-inflammatory adhesion of the duct w...

background:the aim of this study was to investigate the education board of mashhad university of medical sciences on the edo and edc, and their awareness of, attitude towards, and satisfaction with these centers. methods: in this descriptive study, all the members of the education board of mashhad university of medical sciences in the basic and clinical departments were taken as the target grou...

BACKGROUND Transient exposures may influence fertility and early embryonic development. To assess the time of conception in vivo and conduct concurrent biomonitoring, ovulation must be identified prospectively. We report on the development and validation of a simple, prospective method, the Peak Day method, to determine likely day of ovulation based upon daily observations of cervical fluid. ...

a Research Office, Hospital General de México O.D., Mexico City, Mexico b Department of Endoscopy, Instituto Nacional de Cancerología, Mexico City, Mexico c Medical Biological Research Institute, Universidad Veracruzana, Veracruz, Ver., Mexico d Department of Clinical Studies, Takeda-México, Naucalpan, Edo. Mex., Mexico e Medical Office, Takeda-México, Naucalpan, Edo. Mex., Mexico f Laboratory ...

Background: To compare transrectal ultrasonography (TRUS) and TRUS-guided seminal vesicle aspiration in the diagnosis of ejaculatory duct obstruction (EDO). comparing the findings of TRUS and TRUS-guided seminal vesicle (SV) aspiration. Materials and Methods: Design: A retrospective case-controlled study comparing the findings of TRUS and TRUS-guided seminal vesicle (SV) aspiration. Setting: Cl...