نتایج جستجو برای: e4

تعداد نتایج: 3623  

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017
Benjamin C Trumble Jonathan Stieglitz Aaron D Blackwell Hooman Allayee Bret Beheim Caleb E Finch Michael Gurven Hillard Kaplan

The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer's disease (AD). The E4 allele is especially prevalent in some tropical regions with a high parasite burden. Equatorial populations also face a potential dual burden of high E4 prevalence combined with parasitic i...

Journal: :Journal of virology 2007
Sang-Hyuk Chung Kristopher K Frese Robert S Weiss B V Venkataram Prasad Ronald T Javier

Human adenovirus type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determinant of this virus is the E4-ORF1 oncogene, as opposed to the well-known E1A and E1B oncogenes. The tumorigenic potential of E4-ORF1, as well as its ability to oncogenically stimulate phosphatidylinositol 3-kinase (PI3K), depends on a carboxyl-terminal PDZ domain-binding motif (P...

2015
Maria Magdalena Montt-Guevara Maria Silvia Giretti Eleonora Russo Andrea Giannini Paolo Mannella Andrea Riccardo Genazzani Alessandro David Genazzani Tommaso Simoncini

Estetrol (E4) is a natural human estrogen that is present at high concentrations during pregnancy. E4 has been reported to act as an endogenous estrogen receptor modulator, exerting estrogenic actions on the endometrium or the central nervous system but presenting antagonistic effects on the breast. Due to these characteristics, E4 is currently being developed for a number of clinical applicati...

2017
Jing Qian Frank J Wolters Alexa Beiser Mary Haan M Arfan Ikram Jason Karlawish Jessica B Langbaum John M Neuhaus Eric M Reiman J Scott Roberts Sudha Seshadri Pierre N Tariot Beth McCarty Woods Rebecca A Betensky Deborah Blacker

BACKGROUND With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genet...

Journal: :Electrophoresis 2016
Yuqin Qin Lin Qiu Haifang Qin Shumin Ding Li Liu Yiwan Teng Yao Chen Cheli Wang Jinchen Li Jianhao Wang Pengju Jiang

Herein, we report a technique for detecting the fast binding of antibody-peptide inside a capillary. Anti-HA was mixed and interacted with FAM-labeled HA tag (FAM-E4 ) inside the capillary. Fluorescence coupled capillary electrophoresis (CE-FL) was employed to measure and record the binding process. The efficiency of the antibody-peptide binding on in-capillary assays was found to be affected b...

Journal: :Dementia and geriatric cognitive disorders extra 2016
Angela J Hanson William A Banks Hector Hernandez Saucedo Suzanne Craft

BACKGROUND Glucose intolerance and apolipoprotein ε4 allele (E4+) are risk factors for Alzheimer's disease (AD). Insulin sensitizers show promise for treating AD, but are less effective in E4+ individuals. Little is known about how the APOE genotype influences glucose metabolism. METHODS Cross-sectional analysis of 319 older adults who underwent oral glucose tolerance tests; a subset had insu...

Journal: :Circulation research 2001
S Rafii S Dias S Meeus K Hattori R Ramachandran F Feuerback S Worgall N R Hackett R G Crystal

Intravascular introduction of replication-deficient adenoviral vectors (Advectors) provides an ideal model of delivery of transgenes for the treatment of various vascular abnormalities. On the basis of the knowledge that Advectors can induce inflammatory responses after intravascular administration, we speculated that cellular activation by Advector infection could directly modulate the endothe...

Journal: :Journal of virology 2004
Gillian L Knight John R Grainger Phillip H Gallimore Sally Roberts

Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type 1 (HPV1)-induced warts, N-terminal sequences are progressively cleaved from t...

2017
Jennifer Biryukov Jocelyn C. Myers Margaret E. McLaughlin-Drubin Heather M. Griffin Janice Milici John Doorbar Craig Meyers

The most highly expressed protein during the productive phase of the human papillomavirus (HPV) life cycle is E1^E4. Its full role during infection remains to be established. HPV E1^E4 is expressed during both the early and late stages of the virus life cycle and contributes to viral genome amplification. In an attempt to further outline the functions of E1^E4, and determine whether it plays a ...

2016
Knut A Hestad Knut Engedal Jon Elling Whist Per G Farup

INTRODUCTION Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the Apolipoprotein E e4 allele (ApoE e4). The aim of this study was to examine how ApoE e4 was related to blood pressure (BP) in patients with depression and a control group. METHOD...

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