Background: Though manageable, major depressive disorder remains an underdiagnosed and undertreated condition. The objective of this study was to assess the effectiveness safety 8 weeks treatment with tricyclic antidepressant dosulepin hydrochloride in patients episodes not responsive 4 consecutive a single selective serotonin reuptake inhibitor (SSRI).Methods: Patients diagnosed episode withou...

The paper is dedicated to the research output presented at jubilee 50th edition of international scientific conference Synthesis and Analysis Drugs 2022 (SAL), which was organized hosted by Faculty Pharmacy Masaryk University in Brno. Since its launch 1971, when Jozef Čižmárik from Comenius Bratislava started organizing SAL, significant progress medicinal chemistry has been documented every yea...

BACKGROUND Self-poisoning is a common method of suicide and often involves ingestion of antidepressants. Information on the relative toxicity of antidepressants is therefore extremely important. AIMS To assess the relative toxicity of specific tricyclic antidepressants (TCAs), a serotonin and noradrenaline reuptake inhibitor (SNRI), a noradrenergic and specific serotonergic antidepressant (Na...

1 Based on the single case reported by the authors, they suggested that the decrease in the height of R wave and R/S ratio in lead aVR may be related to the level of consciousness and be informative in predicting recovery from toxicity following tricyclic antidepressant (TCA) overdose. 1 I think there are a few problems with this suggestion. For instance, the reason for altered consciousness in...