Noradrenergic fibers innervate the entire cerebral cortex, whereas the cortical distribution of dopaminergic fibers is more restricted. However, the relative functional impact of noradrenalin and dopamine receptors in various cortical regions is largely unknown. Using a specific genetic label, we first confirmed that noradrenergic fibers innervate the entire cortex whereas dopaminergic fibers w...

In the absence of efficient disease-modifying treatments for Parkinson’s disease (PD), research has focused on identifying potential environmental factors whose modulation may prevent or slow progression this neurodegenerative disorder. Compelling epidemiological evidence suggests that caffeine consumption is inversely associated with risk developing PD. Further experimental findings demonstrat...

In order to gain insight into a possible modulatory role for mu, delta, and kappa opioid receptors of the nigrostriatal dopaminergic pathway, we investigated the topographical organization of the receptors with respect to pre- and postsynaptic membranes. Dopaminergic terminals projecting from the substantia nigra to the corpus striatum were destroyed by unilateral injection of 6-hydroxydopamine...

Introduction. There is evidence that neurotransmitters and their systems may be involved in the pathophysiology of motor stereotypies Autism Spectrum Disorder. Objective. Conduct a review to assess on correlations between stereotyped behaviors changes neurotransmitter systems, by analyzing original articles an animal model. Method. Studies published January 2000 2021 were searched six databases...

Melanocortinergic and dopaminergic systems are widely distributed in the CNS and have been established as a crucial regulatory component in diverse physiological functions. The pharmacology of both melanocortinergic and dopaminergic systems including their individual receptors, signaling mechanisms, agonists and antagonists has been extensively studied. Several lines of evidence showed that the...

The role of dopamine receptors in the modulation of nucleus accumbens noradrenaline release was investigated in superfused rat brain slices. At concentrations of </=1 microM, dopamine enhanced, whereas at higher concentrations dopamine inhibited electrically evoked [3H]noradrenaline release. The D1 receptor agonist SKF-38393 increased, whereas the D2 agonist quinpirole inhibited evoked [3H]nora...

Introduction : The present study is aimed at investigation of the mechanism action a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) exhibiting antidepressant properties, in several tests neuropharmacological interaction. Materials and methods To N-199/1, its effect on 5-hydroxytryptophan (5-HTP)-induced head-twitch response (50 mg/kg 300 mg/kg), haloperidol-induced catalepsy (1 are...