The diagnosis and severity of Parkinson's disease are established by clinical criteria. motor manifestations predominate while few sensory. Initially, treatment includes dopaminergic drugs and/or agonists with good results in the first years. Later symptoms appear requiring different therapeutic strategies. Here, we present a series patients late fluctuations treated monosialo-ganglioside. Seve...

BACKGROUND Psychosis is rare in untreated patients with Parkinson's disease (PD) but the prevalence rises to 40% during dopaminergic treatment. So far, no systematic comparison of the psychogenic potential of different dopaminergic drugs had been performed. METHODS Eighty PD patients with psychotic episodes were compared to an age-matched control group of PD patients without psychotic episode...

In the brain, dopamine exerts an important modulatory influence over behaviors such as emotion, cognition, and affect as well as mechanisms of reward and the control of locomotion. The dopamine transporter (DAT), which reuptakes the released neurotransmitter into presynaptic terminals, is a major determinant of the intensity and duration of the dopaminergic signal. Knockout mice lacking the dop...

The midbrain dopaminergic system is a key element in the control of motor activity, cognition, and the motivational effects of drugs of abuse, including nicotine. In this issue of Neuron, Drenan et al. find that alpha6-containing nicotinic acetylcholine receptors might selectively activate mesolimbic and mesostriatal dopaminergic neurons, enhancing striatal dopamine release and its behavioral c...

A statistical analysis between a group of 68 patients with PD and a group of 16 patients with VP showed that the difference in efficacy of dopaminergic drugs was not significant. The comparison was carried out with Chi-Square Test (Table 1). The drugs used in the two groups were L-Dopa and DA. This result suggests two items: 1) it does not seem possible to make a drastic distinction between Par...

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic receptor in supraoptic nucleus. A 75-year-old woman with Parkinson's disease developed asthenia, delirium, aggravated parkinsonia...