OBJECTIVE To study the efficacy of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. STUDY DESIGN Double blind randomized controlled trial. SETTING Department of Obstetrics and Gynecology, Thammasat Hospital, Faculty of Medicine, Thammasat University. MATERIAL AND METHOD Between January 2005 and December 2005, 170 pregnant women who attended at antenatal clin...

The purpose of the present study was to develop intranasal delivery system of dimenhydrinate using thiolated gellan gum and formulations were modulated so as to have gelation at physiological ion content after intranasal administration. Gelation was determined by physical appearance. The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosa, increased with increa...

CONTEXT AND OBJECTIVE Chemotherapy-induced emesis is a limiting factor in treating children with malignancies. Intensive chemotherapy regimens along with emetogenic drug administration have increased the frequency and severity of emesis and nausea. Our study was designed to consider the importance of this problem and the need for improvement in emesis treatment for patients receiving chemothera...

Orodispersible dosage forms are promising new approaches for drug delivery. They enable an easy application, as there is no need to drink high amounts of liquids or swallow large solid dosage forms. The aim of the study was to develop an orodispersible film (ODF) as an alternative to tablets, syrups or suppositories for the treatment of vomiting and nausea, especially for the pediatric populati...

This is a study comparing ondansetron, dimenhydrinate versus placebo as PONV prophylaxis for outpatient gynecologic laparascopy. Postoperative nausea and vomiting (PONV) is very common following ambulatory gynecological laparoscopy. Prophylactic antiemetic therapy if safe, effective and affordable may reduce the incidence of PONV, expedite hospital discharge and improve patient satisfaction. Af...

Stevens-Johnson syndrome is an uncommon inflammatory skin disorder in which immune mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. Herein, an unusual case with strange complaint of"bus allergy" is presented, suffering from severe generalized itching and skin lesions, followed by ulcers in his mouth and genitalia. The diagnosis of Stevens-Johnson syndrome was m...

Searching MEDLINE, EMBASE, and Pre-MEDLINE were searched from 1966 to October 1999 for articles published in the English language. References from retrieved articles were also manually searched. The search terms included 'nausea', 'vomiting', 'emesis', 'postoperative', 'surgery', 'ondansetron', 'granisetron', 'tropisetron', 'dolasetron', 'metoclopramide', 'droperidol', 'prochlorperazine', 'perp...