نتایج جستجو برای: dickkopf

تعداد نتایج: 961  

2015
Katharina Kerschan-Schindl Markus M. Thalmann Elisabeth Weiss Maria Tsironi Ursula Föger-Samwald Johann Meinhart Katerina Skenderi Peter Pietschmann Andrew Philp

BACKGROUND Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated. PURPOSE The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers. M...

2012
Seung Up Kim Jeon Han Park Hyon-Suk Kim Jae Myun Lee Hyun Gyu Lee Hyemi Kim Sung Hoon Choi Shinhwa Baek Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Jong Doo Lee Kwang-Hyub Han

We reviewed the tumor markers for hepatocellular carcinoma, with special reference to the roles of Dickkopf-1 and α-fetoprotein in hepatocellular carcinoma.

2008
Fredrik Agholme Pentti Tengvall Anna Fahlgren

This thesis relates to some new aspects on the regulation of bone healing. In the last few years, Wnt signaling has been shown to play a central role in bone biology. As well as being involved in bone maintenance and repair, Wnt signaling has been presented as one of the ke y pathways through which bone responds to mechanical load. Two secreted extracellular inhibitors of Wnt signaling, scleros...

Abbasian S, Ghaffari K, Ghasemi A, Ghotaslou A, Mohammadi M,

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA methylation such as CDKN2B & p73. Wnt inhibitory factor 1 (WIF1) and Dickkopf-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients. Patients and Methods: ...

2016
Mélody Mazon Delphine Masi Madeleine Carreau

Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologie...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2008

Journal: :The Journal of biological chemistry 2003
Andrea Caricasole Teresa Ferraro Luisa Iacovelli Eliana Barletta Alessandra Caruso Daniela Melchiorri Georg C Terstappen Ferdinando Nicoletti

WNT factors represent key mediators of many processes in animal development and homeostasis and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). In mammals, 19 genes encoding Wingless and Int-related factor (WNTs), 10 encoding Frizzled, and 2 encoding LRP proteins have been identified, but little is known of the identities ...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2019

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