Progestins are widely used as oral contraceptives and hormone replacement therapy. Recently it has been demonstrated that many progestins are inhibitors of P-glycoprotein, possibly explaining gender differences in drug actions. In vitro evidence suggested that at least norgestimate might also inhibit other transporters like the multidrug resistance-associated protein 2 (MRP2). We therefore inve...

Background: A progestogen-only contraceptive is using of Medroxy progesterone acetate, which prevent inhibits ovulation for several months. The purpose of this study was to evaluate changes in metabolic parameters after three and six month use of Depot Medroxy progesterone Acetate (DMPA) in female volunteers. Materials and methos: Triglyceride, Cholesterol, HDL-Cholesterol and LDL-cholesterol...

the objective of the present study was to compare the impact of ovsynch and progesterone-based ovulation synchronization protocol on ovarian response and conception in buffalo (n=19) exhibiting subestrus during low-breeding season (maximum ambient temperatures and relative humidity ranging from 36-45°c and 30-80%, respectively). group i buffalo (n=10) were administered ovsynch protocol (d 0 and...

OBJECTIVE Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women. This study examined whether progestins affect the stimulatory effect of estrogens on the endothelial formation of nitric oxide (NO), a potent antithrombotic factor. METHODS AND RESULTS Experiments were performed with human endothelial cells. Endothelial NO synthas...

Objectives—Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women. This study examined whether progestins affect the stimulatory effect of estrogens on the endothelial formation of nitric oxide (NO), a potent antithrombotic factor. Methods and Results—Experiments were performed with human endothelial cells. Endothelial NO synthase...

The objective of the present study was to compare the impact of ovsynch and progesterone-based ovulation synchronization protocol on ovarian response and conception in buffalo (n=19) exhibiting subestrus during low-breeding season (maximum ambient temperatures and relative humidity ranging from 36-45°C and 30-80%, respectively). Group I buffalo (n=10) were administered ovsynch protocol (d 0 and...

Recent studies (e.g. Blackmore, P. F., Beebe, S. J., Danforth, D. R., and Alexander, N.) (1990) J. Biol. Chem. 265, 1376-1380) have shown that in human sperm, progesterone produces a rapid increase in intracellular free calcium ([Ca2+]i) and an induction of the acrosome reaction (e.g. Osman, R. A., Andria, M. L., Jones, A. D., and Meizel, S. (1989) Biochem, Biophys. Res. Commun. 160, 828-833). ...

Data regarding the effects of progesterone and a progestagen on human normal breast epithelial cell proliferation and apoptosis are presented here. In postmenopausal women, adding progesterone to percutaneously administrated oestradiol significantly reduces the proliferation induced by oestradiol. In vitro and in premenopausal women, stopping the administration of nomegestrol acetate triggers a...

(i) Objective: This study was conducted to analyze the effect of lead acetate on the serum estrogen and progesterone levels in adult mice and the role of garlic extract. (ii) Study Design: Laboratory based Randomized Control Trial. (iii) Place and duration of study: Anatomy Department, Army Medical College, Rawalpindi in collaboration with National Institute of health from April-June 2013. (iv)...