Retinoic acid has been known to play a key role in the regulation of bone cell differentiation and function. The effects of retinoic acid on human dental pulp cells, which contain several characteristics similar to those of bone cells, has yet to be elucidated extensively. The effects of retinoic acid on human dental pulp cells in terms of type I collagen and osteocalcin induction were investig...

Aim of study. To evaluate the outcome of direct pulp capping procedures in permanent teeth performed by postgraduate students during their training program in Endodontics. Material and Methods. 39 patients with dental pulp exposures were evaluated clinically and radiologically after direct pulp capping procedure and followed for at least 24 months. The results were considered successful if the ...

Teeth have been recognized as providing a useful long-term record of lead (Pb2+) uptake. However, information regarding the effects of lead on dental pulp tissue cells that foster dentinogenesis is scarce. This study investigated the effects of lead on dental pulp tissue using human dental pulp fibroblasts in vitro. Dental pulp cells from the teeth of young patients (aged 17-24 years) were cult...

Epidemiological studies have shown that the prevalence of dental erosion in children varies widely between 2 and 57%. Changes seen in dental erosion range from removal of surface characteristics to extensive loss of tooth tissue with pulp exposure and abscess formation. Symptoms of dental erosion range from sensitivity to severe pain associated with pulp exposure. The etiology of dental erosion...

Interactions between ingrowing nerve fibers and their target tissues form the basis for functional connectivity with the central nervous system. Studies of the developing dental pulp innervation by nerve fibers from the trigeminal ganglion is an excellent example of nerve-target tissue interactions and will allow specific questions regarding development of the dental pulp nerve system to be add...

In this study, we have done an immunohistochemical and an electron microscopy examination of normal and inflamed human dental pulp specimens in order to evaluate the morphological aspects of the nerve structures from the dental pulp. The S100 protein immunohistochemical marking allowed us to observe the trajectory of the pulp nervous structures, which appear as continuous bands of high intensit...

Regeneration of dental pulp after pulpectomy was accomplished recently by autologous transplantation of dental pulp stem/ progenitor cells into the root canal. The identical patterns of qualitative and quantitative protein and mRNA expression in the regenerated pulp and normal pulp demonstrated complete pulp regeneration. The lack of tissue specific markers in the dental pulp is a major challen...

Bioactive growth factors identified within the extracellular matrix of dentine have been proposed roles in regulating the naturally inherent regenerative dentine formation seen in teeth in response to trauma and infection, which may also be harnessed for novel clinical treatments in augmenting mineralised tissue repair. This study examined the specific biological action of demineralised dentine...

introduction: the partial removal of dental caries aiming to maintain the integrity of the pulp has been considered the therapy of choice in the treatment of deep carious lesions, as long as certain principles of diagnosis are respected. dentists are always looking for techniques to remove the decayed tissue with biosafety, what provides more comfort to the patient especially when it comes to c...