نتایج جستجو برای: d1b
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Background. The CCND1 gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of a common A/G polymorphism. Cyclin D1a and b proteins differ in their C-terminus, a region involved in protein degradation and sub-cellular localization. Recent data have suggested that cyclin D1b could be a nuclear oncogene. The presence of cyclin D1b mRNA and protein has been stud...
The endopeptidase marker Ep-D1b and Sequence Tag Site (STS) marker XustSSR2001–7DL were reported to be closely associated with the most effective resistance gene (Pch1) in wheat (Triticum aestivum L.) for strawbreaker foot rot [Pseudocercosporella herpotrichoides (Fron) Deighton]. Our objectives were to: (i) develop an efficient assay method for Ep-D1b in wheat; (ii) correlate endopeptidase zym...
PURPOSE Cyclin D1 is found on 11q13, which is a region frequently amplified in several tumor types. The CCND1 locus gives rise to at least two protein isoforms of D1 (D1a and D1b). A common G/A polymorphism (G/A870) is thought to influence the expression levels of D1a and D1b. D1b has been suggested to be increased in the presence of the A allele and more oncogenic than D1a. Furthermore, the A ...
Kernel hardness is one of the most important characterizations on end-use quality of bread wheat and also used for their marketing classification. Kernel texture, mainly controlled by one major locus (Ha) located on the short arm of chromosome 5D. Two tightly linked genes as puroindolin a , and b covered by this major locus and designed as Pina and Pinb respectively. When both puroindolines are...
These notes about the activities of the two Spanish Collaborating Research Groups (CRG) at the Institut Laue Langevin (ILL) are written to give a historical view of the group and to present the two new instrumental projects currently in development. After a brief description of the instruments with current Spanish participation (D1B and D15), it will be presented the project of construction of ...
Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary. Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers. Cyclin D1 (CCND1) undergoes alterna...
PURPOSE Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged. EXPERIMENTAL DESIGN First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas. Second, releva...
Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that a...
Kernel hardness is one of the most important characterizations on end-use quality of bread wheat and also used for their marketing classification. Kernel texture, mainly controlled by one major locus (Ha) located on the short arm of chromosome 5D. Two tightly linked genes as puroindolin a , and b covered by this major locus and designed as Pina and Pinb respectively. When both puroindolines are...
grain hardness is one of the most important quality characteristics of cultivated bread wheat (triticum aestivum l.) that has main effect on milling yield, particle size, and water absorption of wheat flour. kernel hardness is mainly controlled by ha locus on the short arm of chromosome 5d in bread wheat. in this study, we have employed a multifaceted approach to investigate aspects of grain ha...
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