The serum concentrations of cortisol and cortisone were measured in 19 healthy dogs and in 13 dogs with pituitary-dependent hyperadrenocorticism (PDH) before and one hour after an injection of synthetic adrenocorticotropic hormone (ACTH). In the dogs with pdh, the cortisol and cortisone concentrations were measured before and after one to two weeks and three to seven weeks of treatment with tri...

Latent corynebactenai infection occurs naturally in many strains of mice. It can be evoked into the active disease, pseudotuberculosis, by a single injection of 10 mg of cortisone. The cortisone effect was tested in 21 colonies, representing 11 genetically different strains of mice. Animals of the C57B1/6, DBA/2, and RIII strains were shown to be latently infected with Corynebacterium kutscheri...

The incidence of hepatic metastases in rats subjected to intraportal injection of 5,000 Walker 256 carcinosarcoma cells was similar in rats receiving cortisone and their pair-fed controls. This result was obtained whether cortisone was given prior to, after, or preceding and following the injection of tumor cells. Both cortisone-treated and pair fed control rats exhibited significantly fewer me...

Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the ...

I read with interest the Clinical Vista Brief about bilateral hip avascular necrosis. I note that the corticosteroid injection was given 8 months before the condition was diagnosed, but the patient had complained of hip pain for 13 months. Cortisone injections (particularly bursa and tendon sheath infiltrations) are extremely common treatments in primary care, but avascular necrosis is rarely s...

Cortisone acetate (Long & Miles, 1950) and hydro. cortisone (Long & Spensley, 1954) depress sensitivity to tuberculin in guinea pigs. This desensitization does not occur in guinea pigs mildly deficient in ascorbic acid, and is thought to be associated with the oxidation of ascorbic acid to dehydroascorbic acid. There appears to exist an antagonism between corticosteroid desensitizing agents and...

Glycyrrhizin has been clinically used as an anti-allergic agent, but its mechanism remains unknown. This study was undertaken to examine the effect of glycyrrhizin on thymolytic and immunosuppressive action of cortisone in normal rabbits and adrenalectomized rats. Immunization was performed by injection of bacterial a-amylase emulsified in Freund's incomplete adjuvant. Antibody titer of the ser...

IN previous communications (Gordon and McLean, 1950; McLean and others, 1951; Gordon and others, 1951) this group has reported its experiences in the treatment of ocular disease with the use of corticotropin (ACTH) and cortisone. The present paper summarizes our knowledge of the clinical use of corticotropin and cortisone in ophthalmology and adds experiences with hydrocortisone during the past...

SUMMAEY The effect of cortisone (total dose--~4 rag/rat and 12 mg/mouse) on the distribution of fluorene-2,7-di(sulfonamido-2-naphthalene)-S 35 6 hours following intravenous injection of this compound into Wistar rats and CAF~/Jax mice was studied. Both sexes and species treated with cortisone showed significant reduction in the weights of thymus and spleen, except that there was no effect on t...

SUMMAEY The effect of cortisone (total dose--~4 rag/rat and 12 mg/mouse) on the distribution of fluorene-2,7-di(sulfonamido-2-naphthalene)-S 35 6 hours following intravenous injection of this compound into Wistar rats and CAF~/Jax mice was studied. Both sexes and species treated with cortisone showed significant reduction in the weights of thymus and spleen, except that there was no effect on t...