Frailty models are used in the survival analysis to account for the unobserved heterogeneity in individual risks to disease and death. To analyze the bivariate data on related survival times (e.g. matched pairs experiments, twin or family data), the shared frailty models were suggested. Shared frailty models are used despite their limitations. To overcome their disadvantages correlated frailty ...

This talk gives an overview about the analysis of twin data on diseases, aging and longevity. One goal of our research in this area is the evaluation of the genetic contribution to life span and mortality from different causes. Such evaluation is performed using the idea of correlated frailty. We apply different correlated frailty models to the analysis of bivariate survival data from Danish, F...

Frailty is an age-related syndrome that has been well-described in the last ten years. It can be characterized by diminished strength, endurance, and reduced physiologic function. With multiple causes and contributors, frailty is highly correlated with functional decline and chronic diseases. Currently, there are no standardized tests or biomarkers that can be used to identify frail patients, t...

This document contains results and other material that is supplementary to Duffie, Eckner, Horel, and Saita (2009). Section I extends the basic model to allow for unobserved cross-sectional heterogeneity of default risk. Section II allows for a nonlinear dependence of default intensity on distance to default, through a simple non-parametric specification. Section III provides some information o...

We present the frailtyHL package for fitting semi-parametric frailty models using hlikelihood. This package allows lognormal or gamma frailties for random-effect distribution, and it fits shared or multilevel frailty models for correlated survival data. Functions are provided to format and summarize the frailtyHL results. The estimates of fixed effects and frailty parameters and their standard ...

Background. A geriatric evaluation and management unit (GEM) manages elderly inpatients with functional impairments. There is a paucity of literature on frailty and whether this impacts on rehabilitation outcomes. Objectives. To examine frailty score (FS) as a predictor of functional gain, resource utilisation, and destinations for GEM patients. Methods. A single centre prospective case study d...