statement of problem: recurrent aphthous stomatitis (ras) is one of the most common diseases affecting human oral mucosa. the etiology of this disease remains unclear; therefore a definitive treatment has not yet been established and corticosteroids might be prescribed to reduce the symptoms associated with ras. purpose: the aim of this study was to determine the effects of a mouthwash containi...

Clobetasol benefits to control psoriasis lesions are well defined, but there were not studies about its action when used in lacquer vehicle to control skin lesions. A double-blind study was conducted with 40 patients that utilized clobetasol 0.05% in one hemibody and just the vehicle in the other hemibody. Twenty of them used petrolatum as vehicle and the others used lacquer. An assessment was ...

BACKGROUND Nail psoriasis may affect up to 90% of patients with psoriasis in the course of the disease throughout their lives and it is often a therapeutic challenge to dermatologists. Topical treatments described in the literature have demonstrated variable efficacy, and unsatisfactory results have been associated to inefficient penetration of the active ingredient into the nail plate and prox...

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the pat...

OBJECTIVE To assess the safety and efficacy of topical 0.1% tacrolimus vs 0.05% clobetasol propionate. DESIGN Randomized double-blind trial. SETTING Department of Dermatology, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí, México. PARTICIPANTS From 20 children with vitiligo, 2 symmetrical lesions of about the same size and evolution time were selected. They were devoid of an...

Cleaning validation is required in the pharmaceutical field to avoid potential clinically significant synergistic interactions between pharmacologically active chemicals. A simple, sensitive and accurate HPLC method has been developed and validated for determination of Clobetasol Propionate residues on the surface of manufacturing equipement. Separation of Clobetasol Propionate and Related comp...

Cip-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication and has been implicated in the tumorigenesis of breast cancer cells. In order to investigate the possibility of using medicinal glucocorticoids against breast cancer, we studied whether certain glucocorticoids affect the expression of Ciz1. The in vitro effect of clobetasol tr...

BACKGROUND Lichen sclerosus (LS) is a chronic inflammatory dermatosis that occurs mainly in the anogenital area and causes itching and soreness. Progressive destructive scarring may result in burying of the clitoris in females and phimosis in males. Affected people have an increased risk of genital cancers. OBJECTIVE We sought to assess the effects of topical interventions for genital LS. M...

BACKGROUND Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity. OBJECTIVE We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment for the treatment of OLP. PATIENTS AND METHODS A total of 32 patients (20 females and 12 males; all white, Italian origin, mean age of 43.6+/-18.4 years; 16 patien...