Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002-2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in ...

BACKGROUND AND OBJECTIVES Resistance in Salmonella enterica var Typhi (S. Typhi) to chloramphenicol, amoxicillin and co-trimoxazole has posed a challenge to treatment of typhoid fever. Ciprofloxacin has been the empirical therapy of choice, but the recent increase in minimum inhibitory concentration (MIC) to ciprofloxacin in S. Typhi, not detectable by disc diffusion (DD) tests, may result in d...

Background: Acinetobacter baumannii is one of the causes of nosocomial infections, especially in the intensive care unit. The emergence of multidrug-resistant strains of A. baumannii has caused many problems. One of the ways to handle the phenomenon of antibiotic resistance is the use of herbal medicines and their derivatives in place of or in combination with antibiotics. The aim of this study...

staphylococcus aureus causes a wide variety of infections worldwide. methicillin-resistant s. aureus is one of most common causes of nosocomial and community acquired infections. the fluoroquinolones are an important class of antibiotics that used to treat infections caused by s. aureus. today, a significant increase in the rate of ciprofloxacin resistance in methicillin-resistant s. aureus str...

Ciprofloxacin, a quinolone with good intracellular penetration may possibly be used for treatment of melioidosis caused by Burkholderia pseudomallei, but problems with resistance may be encountered. Amino acid substitutions in gyrA/gyrB have given rise to fluoroquinolone resistance in various microorganisms. Using published primers for gyrA and gyrB, PCR was performed on 11 isolates of B. pseud...

Enteric fever is the major diagnosis among febrile patients in Nepal with yearly increase in nalidixic acid resistance and reduced ciprofloxacin susceptibility among Salmonella isolates. This study was carried out to evaluate the validity of nalidixic acid resistance as an indicator of reduced susceptibility of Salmonella isolates to ciprofloxacin. In this study, 999 blood specimens collected f...

Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment of infections. Nanomedicines such as chitosan can carry multiple drugs and improve the therapeutic effects of antibiotics. Objectives: The study aimed to synthesis and characterization of ciprofloxacin loaded chitosan nanoparticle for eradication biofilm of P. aeroginosa. Methods: Cipro-CS microparticles...

OBJECTIVES To define the genetic characteristics and resistance mechanisms of clinical isolates of Salmonella enterica serovar Typhi (S. Typhi) and S. enterica serovar Paratyphi A (S. Paratyphi A) exhibiting high-level fluoroquinolones resistance. METHODS Three S. Typhi and two S. Paratyphi A ciprofloxacin-resistant isolates (MICs > 4 mg/L) were compared with isolates with reduced susceptibil...