Despite advances in immunosuppressive drugs, long-term success of liver transplantation is still limited by the development of chronic liver allograft dysfunction. Although the exact pathogenesis of chronic liver allograft dysfunction remains to be established, there is strong evidence that chemokines are involved in organ damage induced by inflammatory and immune responses after liver surgery....

COMMON CAUSES of renal allograft dysfunction include acute rejection, cyclosporine or FK506 toxicity, acute tubular necrosis, and chronic allograft nephropathy. Important but less frequent causes are recurrent and de novo diseases in the allograft. We report the case of a 66-year-old man who developed renal insufficiency 8 months posttransplantation. A novel cause of renal allograft dysfunction...

OBJECTIVE To explore the expression of Glycogen synthase kinase 3 beta (GSK-3β) in renal allograft tissue and its significance in the pathogenesis of chronic allograft dysfunction. METHODS Renal allograft biopsy was performed in all of the renal allograft recipients with proteinuria or increased serum creatinine level who came into our hospital from January 2007 to December 2009. Among them 2...

Renal biopsy remains the "gold standard" for the diagnosis of renal allograft dysfunction. The aim of our study was to highlight the importance of renal biopsy in the management of allograft dysfunction (early diagnosis and therapeutic approach). Our study included 23 renal allograft biopsies from 20 patients. This retrospective study analyzed the demographic and clinical data, histological res...

Histoplasmosis is caused by the dimorphic fungus - Histoplasma capsulatum. The presentation of histoplasmosis often disseminated, though primary intestinal involvement can rarely be seen in patients with cell mediated immune dysfunction like AIDS. We report a case renal allograft recipient, who had history COVID 19 infection and also underwent anti-rejection treatment for graft dysfunction, pre...