OBJECTIVE Syntometrine is an effective uterotonic agent used in preventing primary postpartum haemorrhage but has adverse effects including nausea, vomiting, hypertension and coronary artery spasm. Carbetocin is a newly developed long-acting oxytocin analogue that might be used as an uterotonic agent. We compare the efficacy and safety of intramuscular (IM) carbetocin with IM syntometrine in pr...

Introduction Recognition of biological properties of Carbetocin [2-0-rnethy~ tyrosine]deamino-l-carba-oxytocin (I) (1-3) resulted in the introduction of this compound into veterinary practice as a drug with selective uterotonic and milk-ejecting action (Depotocin-Spofa and Decomoton-Nordvacc) In order to elucidate further properties j metabolism and distribution of Carbetocin we decided to prep...

background postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. objectives the aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. materials and methods this study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to shabiehkhani maternity cente...

Objective To compare intramuscular oxytocin, Syntometrine® and carbetocin for prevention of postpartum haemorrhage after vaginal birth. Design Randomised double-blinded clinical trial. Setting Six hospitals in England. Population A total 5929 normotensive women having a singleton Methods Randomisation when birth was imminent. Main outcome measures Primary: use additional uterotonic agents. Seco...

BACKGROUND The two most commonly used uterotonic drugs in caesarean section are oxytocin and carbetocin, a synthetic oxytocin analogue. Carbetocin has a longer half-life when compared to oxytocin, resulting in a reduced use of additional uterotonics. Oxytocin is known to cause fewer cardiovascular side effects when administered as a short-infusion compared to as an intravenous bolus. Based on t...

Background: Carbetocin and oxytocin are indicated for the prevention of postpartum haemorrhage (PPH) due to uterine atony. is a newer analogue with longer half life more heat stable. PPH can be effectively reduced by prophylactic use uterotonics. The aims present study were compare effects carbetocin in separation placenta, controlling blood loss additional uterotonic needed caesarean section (...

Induction is usually carried out by administering prostaglandins (prostaglandin F2α or a synthetic analogue). Other hormones, most commonly oxytocin, may also be given. The primary objective is to increase the synchrony of farrowing. This facilitates farrowing supervision, early fostering and 'all in, all out' management of the farrowing house, all of which have the potential to decrease piglet...

are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist...

Postpartum hemorrhage is one of the main causes maternal death. This study compares clinical efficacy and adverse reactions rate between tranexamic acid injection carbetocin in postpartum treatment. We selected 80 cases after vaginal delivery who received therapy Affiliated Hospital Guizhou Medical University from January 2019 to June 2020. And then randomly divided them into experiment group (...

Partus induction is an important integrative component of reproduction management in the swine industry. In this context, the question is to what extent the application of uterotonic substances may influence the vitality of piglets. The blood pH value is used as a laboratory objective diagnostic parameter of neonatal acidosis. This parameter of the acid-base balance was examined in piglets born...