NMR spectroscopy is a powerful technique for determining structural and functional features of biomolecules in physiological solution as well as for observing their intermolecular interactions in real-time. However, complex steps associated with its practice have made the approach daunting for non-specialists. We introduce an NMR platform that makes biomolecular NMR spectroscopy much more acces...

Recent developments in experimental and computational aspects of NMR spectroscopy have had a significant impact on the accuracy and speed of macromolecular structure determination in solution, particularly with regard to systems of high complexity (such as protein complexes). These include experiments designed to provide long-range orientational and translational restraints, improvements in int...

electron components have been steadily decreasing in size, while molecular materials have in recent years been found to exhibit many of the properties used in electronics. such developments are giving rise to a new field in which molecular materials are used for electronic applications. molecular electronics offers .

Molecular sensors and molecular electronics are a major component of a recent research area known as bionanotechnology, which merges biology with nanotechnology. This new class of biosensors and bioelectronics has been a subject of intense research over the past decade and has found application in a wide variety of fields. The unique characteristics of these biomolecular transduction systems ha...

A powerful feature of macromolecular structure analysis by NMR spectroscopy is its potential for automation.1,2 It has been recognized for some time that many of the interactive tasks carried out by an expert in the process of spectral analysis could, in principle, be carried out more efficiently and rapidly by computational systems. Manual methods of protein data analysis often involve using l...

The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer chemosensors many more. Scientists likewise dedicated to investigating the possibilities AIEgens biomedical fie...

~Protein Engineering Network of Centres of Excellence, Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2S2 bDepartment of Molecular Biology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, US.A. "National Magnetic Resonance Facility at Madison, Department of Biochemistry, University of Wisconsin at Madison, 420 Henry Mall, Madison, ...

The interpretation of residual dipolar couplings in terms of molecular properties of interest is complicated because of difficulties in separating structural and dynamic effects as well as the need to estimate alignment tensor parameters a priori. An approach is introduced here that allows many of these difficulties to be circumvented when data are acquired in multiple alignment media. The meth...