Objective:Platycladus orientalis or Thuja orientalis is a native plant of Iran different parts of which are used in the treatment of various diseases such as: gout, rheumatoid arthritis, common cold, cough, bronchitis, asthma, high blood pressure and hormonal disorders like hirsutism and baldness. Also, various organs of this species have been used as appetizer. The purpose of this study was to...

Abstract: Background: Phytosome is a novel technique introduced by Indena that combines standardised herbal extract and phospholipid in preferably equal ratio to provide better absorption enhancing bioavailability. Purpose: The objective of proposed study prepare, optimise characterize phytosomes Murraya koenigii (Linn.) Spreng improve its antidiabetic properties. Materials Methods: Antisolvent...

Silymarin, a flavonolignan derived from Silybum marianum, possesses diverse pharmacological activities, including hepatoprotective, antioxidant, anti-inflammatory, anticancer, and cardioprotective. Although clinical trials have shown silymarin is safe at high doses (>1500 mg/day) in humans, the pharmacokinetic studies over the past three decades related to absorption, distribution, metabolism, ...

Abstract: Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine has been hindered for long time due to its poor solubility low bioavailability. This study aims design liposomes-gel enhance bioavailability activity hydrochloride. Materials Metho...

Aloe vela leaf gel extract (AGE) are widely used as cosmetic and pharmaceutical ingredients because of its versatile skin care properties. In order to enhance the bioavailability of AGE, liposomes encapsulating AGE were prepared and examined for their interfacial and biochemical properties. The liposomes prepared from a soybean lecithin (SLP-WHITE, 1.0 wt%) by the Bangham method gave relatively...

Plant-derived polyphenols are increasingly gaining attention as dietary supplements for their multidimensional role in homeostatic management of inflammation, to support detoxication, and for anticancer, weight loss, and many other benefits. Many plants extracts rich in flavonoids and polyphenolics have been extensively explored for their pro-homeostatic effects on genes, transcription factors,...

BACKGROUND The objective of this study was to develop a novel polydatin (PLD)-loaded liposome system using the thin film hydration technique. METHODS The delivery system was characterized in terms of morphology, size, zeta potential, encapsulation efficiency, and in vitro release. In addition, a pharmacokinetic study was carried out in rats after oral administration of PLD-loaded liposomes in...

Objectives: The main objective of the present work is to enhance bioavailability ellagic acid (EA) by increasing its dissolution there allowing for exploitation therapeutic effects. Methods: Phytosomes containing EA were prepared anti-solvent precipitation method. phytosomes evaluated drug entrapment efficiency, in vitro release, and excipient interaction studies. Results: Formulation F2 soya l...

Over the past decade, major advances have been made on development of novel drug delivery systems (NDDS) form plant actives and extracts. Herbal medicines have been widely used all over the world since ancient old ages and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. Herbal therapeutics c...