The accuracy of the binned kernel density estimator is studied for general binning rules. We derive mean squared error results for the closeness of this estimator to both the true density and the unbinned kernel estimator. The binning rule and smoothness of the kernel function are shown to innuence the accuracy of the binned kernel estimators. Our results are used to compare commonly used binni...

Metagenomic binning methods that leverage differential population abundances in microbial communities (differential coverage) are emerging as a complementary approach to conventional composition-based binning. Here we introduce GroopM, an automated binning tool that primarily uses differential coverage to obtain high fidelity population genomes from related metagenomes. We demonstrate the effec...

We introduce a new metric, the visible signal-to-noise ratio (vSNR), to analyze how pixel-binning and resizing methods influence noise visibility in uniform areas of an image. The vSNR is the inverse of the standard deviation of the SCIELAB representation of a uniform field; its units are 1/ΔE. The vSNR metric can be used in simulations to predict how imaging system components affect noise visi...

More and more developed and inexpensive next-generation sequencing (NGS) technologies allow us to extract vast sequence data from a sample containing multiple species. Characterizing the taxonomic diversity for the planet-size data plays an important role in the metagenomic studies, while a crucial step for doing the study is the binning process to group sequence reads from similar species or t...

Color is one of the most important and easily identifiable features for describing the visual content. The MPEG standard has developed a number of descriptor that covers different aspects of the visual content. Dominant color descriptor is one of them. This paper proposes a channelized binning approach, a novel method for extraction of dominant color pixel value, which is a variant of dominant ...

This note argues that when dot-plotting distributions typically found in papers about web and social networks (degree distributions, component-size distributions, etc.), and more generally distributions that have high variability in their tail, an exponentially binned version should always be plotted, too, and suggests Fibonacci binning as a visually appealing, easy-to-use and practical choice.

Metagenomics-based studies of mixed microbial communities are impacting biotechnology, life sciences and medicine. Computational binning of metagenomic data is a powerful approach for the culture-independent recovery of population-resolved genomic sequences, i.e. from individual or closely related, constituent microorganisms. Existing binning solutions often require a priori characterized refer...

We introduce a new metric, the visible signal-to-noise ratio (vSNR), to analyze how pixel-binning and resizing methods influence noise visibility in uniform areas of an image. The vSNR is the inverse of the standard deviation of the SCIELAB representation of a uniform field; its units are 1/ΔE. The vSNR metric can be used in simulations to predict how imaging system components affect noise visi...

We develop novel methods for recognizing and cataloging conformational states of RNA, and for discovering statistical rules governing those states. We focus on the conformation of the large ribosomal subunit from Haloarcula marismortui. The two approaches described here involve torsion matching and binning. Torsion matching is a pattern-recognition code which finds structural repetitions. Binni...

Epitope Binning # 6.140522 An important step in the engineering of biotherapeutics is to characterize and group a library of monoclonal antibod-ies by the epitope binding regions generated against a specific antigen. This “epitope binning” enables the maintenance of epitope diversity and provides important information to broaden intellectual property protection. IBIS Technologies and Wasatch Mi...