introduction: vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify immunohistochemical changes that occur in the pancreatic beta ([pancreatic islet beta]) cells of vanadyl sulphate (vs) treated stz induced diabetic rats. materials and methods: male wistar rats were made diabetic with injecting a single intr...

Objective: MafA is one of the major factors in the family of MafA transcription factors. In pancreatic beta cells, MafA plays an important role in regulating the expression of glucose-dependent Insulin gene. On the other hand, Lipotocyticleads to negative expression of MafA expression when exposed to inflammatory cytokines. These statements in general emphasize the role that MafA plays as a key...

results apoptosis induced by pa in ins-1 cells was significantly resolved after liraglutide treatment. simultaneously, autophagy was enhanced with the treatment of pa and liraglutide. conclusions: liraglutide appears to protect ins-1 cells from apoptosis ffa-induced by promoting autophagy. conclusions these findings provide a novel role for glp-1 analogue in preventing or treating with t2d. obj...

introduction: although aging is the most important risk factor for alzheimer's disease (ad), there is evidence indicating that neuroinflammation may contribute to the development and progression of the disease. several studies indicated that minocycline may exert neuroprotective effects in rodent models of neurodegenerative diseases. nevertheless, there are also other studies implying that...

objective: glioblastoma multiforme (gbm), one of the most common and aggressive malignant brain tumors, is highly resistant to radiotherapy. numerous approaches have been pursued to find new radiosensitizers. we used a picogreen and colonogenic assay to appraise the dna damage and cell death in a spheroid culture of gbm cells caused by iodine-131 (i-131) beta radiation in the presence of topote...

Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic r...

radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma and also in the treatment of graves’ disease. the basis of which is the accumulation of radioactive iodine by the sodium-iodide symporter (nis) in the thyroid gland. expression of nis by extrathyroidal tissues including islets of pancreas has been reported. radioactive iodine uptake ...

background: type-i diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. tnf-related apoptosis-inducing ligand (trail) is a type-ii membrane protein of the tnf superfamily which is expressed in different tissues, including pancreas and lymphocytes. in humans, trail interacts with four membrane receptors. trail-r1 and trail-r2...