INTRODUCTION There are few studies investigating the association between BCG vaccination and atopy or asthma in adults. OBJECTIVE We investigated the association between BCG scar and the occurrence of atopy and asthma in Korean adults. METHODS We carried out a retrospective study of Korean adults who underwent skin prick testing, and, in some cases, spirometry and bronchial provocation test...

INTRODUCTION Bacille Calmette-Guerin (BCG) vaccination remains a routine immunization in primary care in tuberculosis (TB)-endemic areas, though several studies found that its efficacy was inconclusive. Natural resistance-asociated machrophage protein 1 (NRAMP1) polymorphism has been shown to result in higher susceptibility to TB. Information on genetic susceptibility in populations will be use...

the policy of vaccinating children who live with leprosy patients, and who have responses to leprosin a of2rnrn or less, with bcg+killed mycobacterium vaccae if they lack a bcg scar, or with killed m. vaccae alone if they have a bcg scar, has been followed over 3-4 years in two centers in iran. judged on the basis of skin test conversion to leprosin positivity, the policy has been highly succes...

OBJECTIVE To find out the incidence of BCG-scar failure, in BCG vaccinated children and assess their in vitro cellular response. DESIGN Four year prospective cohort observational study. SETTING Immunization centers at: (a) State Tuberculosis Center; (b) Tuberculosis Association of Andhra Pradesh; and (c) Niloufer Hospital for Women and Children in Hyderabad. METHODS Healthy children broug...

the prevalence of atopic disease in recent decades has been dramatically increased. it has been suggested that bcg vaccination may protect against development of allergic diseases. the purpose of this study was to identifying relation between scar of bcg vaccine and atopy. this cross-sectional study was done in 1000 children, 10-15 years of age, in zanjan city. one thousand children (501 girls ...

The tuberculin skin test (TST) as a diagnostic tool for tuberculosis (TB) infection is used in many countries, including Indonesia, but lacks specificity. Interferon-gamma is a highly specific assay because it is not influenced by previous BCG vaccination or non-tuberculous mycobacteria (NTM) infections. We aimed to study the effect of BCG vaccination and NTM infection on the results of the int...

BACKGROUND Vaccination with a recombinant modified vaccinia Ankara expressing antigen 85A from Mycobacterium tuberculosis, MVA85A, induces high levels of cellular immune responses in UK volunteers. We assessed the safety and immunogenicity of this new vaccine in West African volunteers. METHODS AND FINDINGS We vaccinated 21 healthy adult male subjects (11 BCG scar negative and 10 BCG scar pos...

BACKGROUND Delivery of Bacille Calmette-Guréin (BCG) Tokyo vaccine, with the multipuncture device, has been much preferred over BCG Pasteur, with the intradermal method, possibly due to the easier manner of administration, a desire to avoid any trouble with scars, as well as side effects and higher profits to providers in South Korea. METHODS To determine BCG scar status in 0~6 year old child...

OBJECTIVES To determine the sensitivity of the bacillus Calmette-Guérin (BCG) scar as an indicator of previous vaccination and to ascertain the tuberculin skin test (TST) response in infancy after vaccination in a community from an area hyperendemic for tuberculosis (TB). METHODS In a birth cohort of healthy term infants from Lima, Peru, a single dose of BCG vaccine was administered within th...

BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccin...