background cutaneous leishmaniasis is a health problem in the world. lesions should be treated on cosmetically or functionally important sites, such as the face and hands. cantharidin is a terpenoid compound produced naturally by beetles of meloidae and oedemeridae families. objectives the current study aimed to investigate the effect of cantharidin on cutaneous leishmaniasis (cl) lesions and i...

the susceptibility of various strains of mice to infection by leishmania tropica (major) was recently studied in this laboratory. the infection in a/j, c3h, cba, akr/j, akr/cu, and c57b1 mice (the semi resistant strains) remained cutaneous and the animals recovered within 4-6 months. however balb/c mice developed generalized infection after two months of exposure resulting in death 3-4 months l...

background pentavalent antimonials remain the choice of treatment for leishmaniasis, despite their toxicity, high cost, and difficult administration. as an alternative, morphine may induce the healing process of cutaneous leishmaniasis by its immunoregulatory characteristics. objectives to study the effect of morphine on the wound-healing process of cutaneous leishmaniasis (cl) in a mouse model...

this experimental study was conducted to assess of effectiveness of two nanogold concentrations against cutaneous leishmaniasis (cl) caused by iranian strain of leishmania major in balb/c mice model. cutaneous lesions were experimentally induced by inoculation with iranian leishmania major promastigotes (mrho/ir/75/er) in 61 balb/c mice. the infected mice were enrolled to four groups: intervent...

background: leishmaniasis is a worldwide disease prevalent in tropical and sub- tropical countries in the world. characterization of inflammatory responses produced in cutaneous leishmaniasis has not yet been completed. methods: the specific primers were designed for ten pro-inflammatory genes including ccl4, ccl3, tnf-α, il-1α, il-12p35, il-12p40, ccl5, ccr5, il-1β and ifn- γ and their express...

the onset of infections by leishmania parasites mainly caused by amastigote growth inside the macrophages. one of the important properties of lesion-derived amastigote is thought to be the attachment of various host proteins including immunoglobulins on the surface of amastigote. in this study, the presence of immunoglobulins on the surface of lesion-derived amastigotes was detected by western ...

cutaneous leishmaniasis is one of the most important parasitic diseases, which are endemic in different parts of iran.   leishmania major and l. tropica are the primary causative agents of this disease. the aim of the present study was to detect the multiple forms of l. major in lung. ppromastigotes of l. major at stationary phase were injected to balb/c mice. after 60 days, the different forms...