INTRODUCTION The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. OBJECTIVE Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cy...

A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally-acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptiv...

ETHNOPHARMACOLOGICAL RELEVANCE Bacopa monnieri has a long history in Ayurvedic medicine for neurological and behavioral defects. To assess its efficacy in improving cognitive function. MATERIALS AND METHODS MEDLINE, EMBASE, CINAHL, AMED, Cochrane Central of clinical trial, WHO registry, Thai Medical Index, Index Medicus Siriraj library and www.clinicaltrial.gov were searched from the inceptio...

a hydroethanolic extract (he-ext) of bacopa monnieri (bm) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. standard centrally-acting analgesic, morphine (mp), and peripherally-acting one, diclofenac (diclo), were also tested along with the extract for comparison. the extract exhibited significant antinociceptive ...

OBJECTIVES Traditional knowledge suggests that Bacopa monnieri enhances cognitive performance. Such traditional beliefs have now been scientifically tested through a handful of randomized, controlled human clinical trials. The current systematic review aimed to examine the scientific evidence as to whether Bacopa can enhance cognitive performance in humans. DESIGN A systematic review of rando...

BACKGROUND The current therapy of neuropathic pain is inadequate and is limited by the extent of pain relief and the occurrence of dose dependant side effects. Insufficient control of pain with conventional medications prompts the use of complementary and alternative medicine therapies by patients with neuropathic pain. This study therefore investigated a standardized methanolic extract of Baco...

BACKGROUND Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. METHODS Endophytic fungi were isolated from the Bacopa monnieri. Extracts from liquid cultures were tested for cytotoxicity again...

Brahmi (Bacopa monnieri) has been used by Ayurvedic medical practitioners in India for almost 3000 years. The pharmacological properties of Bacopa monnieri were studied extensively and the activities were attributed mainly due to the presence of characteristic saponins called "bacosides." Bacosides are complex mixture of structurally closely related compounds, glycosides of either jujubogenin o...

Bacopa monnieri is a plant used as a nootropic in Ayurveda, a 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role as a memory enhancer, the molecular and cellular mechanism underlying Bacopa's nootropic action are not understood. In this study, we used deep sequencing (RNA-Seq) to identify the transcriptome changes upon Bacopa treatm...

Bacopa monnieri (Linn.) is a highly regarded medicinal plant in Indian traditional Ayurvedic medicine for centuries owing to its broad spectrum bioactivities. The biological effects of B. monnieri are documented in traditional as well as scientific literature. The plant possess many important bioactivities like memory enhancing, anti-oxidant, anti-inflammatory, analgesic, antipyretic, hepatopro...