نتایج جستجو برای: atf6
تعداد نتایج: 724 فیلتر نتایج به سال:
Exposing cells to conditions that modulate growth can impair endoplasmic reticulum (ER) protein folding, leading to ER stress and activation of the transcription factor, ATF6. ATF6 binds to ER stress response elements in target genes, inducing expression of proteins that enhance the ER protein folding capacity, which helps overcome the stress and foster survival. To examine the mechanism of ATF...
BACKGROUND MicroRNA (miRNA) and messenger RNA (mRNA) expression differs in cystic fibrosis (CF) versus non-CF bronchial epithelium. Here, the role of miRNA in basal regulation of the transcription factor ATF6 was investigated in bronchial epithelial cells in vitro and in vivo. METHODS Using in silico analysis, miRNAs predicted to target the 3'untranslated region (3'UTR) of the human ATF6 mRNA...
The transcription factor ATF6 is held as a membrane precursor in the endoplasmic reticulum (ER), and is transported and proteolytically processed in the Golgi apparatus under conditions of unfolded protein response stress. We show that during stress, ATF6 forms an interaction with COPII, the protein complex required for vesicular traffic of cargo proteins from the ER. Using an in vitro budding ...
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UPR)-associated transcription factor ATF6 attenuates secretion and extracellular aggregation of amy...
هدف این پژوهش، بررسی تأثیر تمرین استقامتی بر میزان پروتئین‌های XBP-1 و ATF6 در بافت سیاتیک موش‌های صحرایی نر نژاد ویستار دیابتی بود.پژوهش ازنوع تجربی با طرح پس‌آزمون به‌همراه گروه کنترل بود و به شیوۀ آزمایشگاهی انجام گرفت. در این پژوهش، 32 سر رت 10 هفته‌ای با میانگین وزن 16/10 ± 253 گرم در چهار گروه سالم کنترل، سالم تمرین، دیابت کنترل و دیابت تمرین به‌صورت تصادفی تقسیم شدند. برای القای دیابت پس...
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD during acute stress and reduce FLD during chronic stress. There is little mechanistic understandin...
CONTEXT Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians. OBJECTIVES To investigate the broader significance of this association for DM2, replication studies in distinct ethic populations are required. We inve...
Endoplasmic reticulum (ER) stress-induced activation of ATF6, an ER membrane-bound transcription factor, requires a dissociation step from its inhibitory regulator, BiP. It has been generally postulated that dissociation of the BiP-ATF6 complex is a result of the competitive binding of misfolded proteins generated during ER stress. Here we present evidence against this model and for an active r...
Proper folding of secreted and transmembrane proteins made in the rough endoplasmic reticulum (ER) requires oxygen for disulfide bond formation. Accordingly, ischemia can impair ER protein folding and initiate the ER stress response, which we previously showed is activated in the ischemic heart and in culture cardiac myocytes subjected to simulated ischemia. ER stress and ischemia activate the ...
اکثر مطالعات همراهی پلی مورفیسم های تک نوکلوتیدی دارای مشکل عدم تجدید پذیری هستند که این امر توالی یابی دوباره ژن ها به منظور شناسایی واریانت های نادر جدید و جهش های مضر را ضروری می سازد. در پژوهش های اخیر جهش های عملکردی در توالی پروموتری ژن کلرتیکولین ((calr در طیف بیماران سایکوز گزارش شده است که در جمعیت کنترل وجود ندارد. ژن aft6 (activating transcription factor 6)، یک فاکتور رونویسی مهم و ...
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