This is a short introductory guide to using APML markup to annotate spoken texts and to specify intonation for the FESTIVAL open-source speech synthesizer.

The introduction of all-trans retinoic acid (ATRA) and arsenic trioxide has brought about tremendous advancement in the treatment of acute promyelocytic myelogenous leukemia (APML). In most instances, the benefits of these treatments outweigh the risks associated with their respective safety profiles. Although acute pancreatitis is not commonly associated with arsenic toxicity, it should be con...

Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique...

Arsenic trioxide (As(2)O(3)) has been found effective in the treatment in the treatment of acute promyelocytic leukemia (APML). Most studies with As(2)O(3) involve patients with APML who have relapsed following standard therapy. Between January 1998 and July 2000, 14 patients were recruited for an ongoing trial of As(2)O(3) in the treatment of newly diagnosed APML. Arsenic trioxide was administ...

Acute promyelocytic leukaemia (APML) is a condition classically characterised by t(15;17) (q22, q21), with disseminated intravascular coagulopathy (DIC) being a major cause of death. Central nervous system (CNS) involvement with APML commonly occurs in relapse; however, it is rarely seen at presentation, with only six reported cases in the literature. This case is the first to describe a patien...

Thirty six APML patients achieving hematological remission with As2O3 were serially monitored using RT-PCR. Though only 5.5% achieved molecular remission at induction remission, 94.5% became negative during consolidation. At 20 months follow-up, 85% remain in remission but longer follow up studies are needed to monitor late relapses.

treatment related acute myeloid leukemia (t-aml) is well documented phenomenon after chemotherapy. in this subgroup of patients acute promyelocytic leukemia (apml) due to delayed complication of using anthracycline is very rare occurrence. very few cases are reported in world literature. we are reporting a rare case of occurrence of t-apml in cured breast cancer patient treated with doxorubicin...

To cite: Vourexakis Z. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014205100 DESCRIPTION A middle-aged patient with no major comorbidity presented to the emergency department with severe odynophagia and painful oral lesions of 3 days’ duration, and pronounced fatigue along with unusual recurrent bruising for almost a month. Inspection of the oral cavity (figu...