نتایج جستجو برای: anticonvulsant antitubercular

تعداد نتایج: 6799  

2013
K. N. Venugopala V. Rashmi B. Odhav

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds...

2014
Mohammad Asif

Heterocyclic compounds have paying strong attention interest. Many different derivatives have been prepared and possess various type useful pharmacological activities. A lot of work has been done on five member heterocyclic triazole ring system. Different pharmacological activities of triazole ring and its derivatives have been observed. Triazole derivatives possess a wide range of pharmacologi...

Journal: :Archiv der Pharmazie 2015
Rupinder K Gill Ravindra K Rawal Jitender Bariwal

Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five-membered thiazole ring. This moiety has attracted considerable attention because of its wide range of pharmacological activities such as antitubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, analgesic, anti-inflammatory, antidiabetic, antitumor activity, etc. In the last few years, s...

Journal: :Medicinal research reviews 2014
Rangappa S Keri Asha Hiremathad Srinivasa Budagumpi Bhari Mallanna Nagaraja

The properties of benzimidazole and its derivatives have been studied over more than one hundred years. Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to n...

Mohammad Asif, Mohd Imran

Oxazine derivatives are significant class of heterocycle compounds, which has involved much synthetic attention due to their extensive variety of pharmacological activities. Oxazine is a heterocyclic compound can be formally derived from benzene, and its reduction products, by suitable substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few years oxazine derivatives ...

2014
Anu Kajal Suman Bala Neha Sharma Sunil Kamboj Vipin Saini

Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazon...

2014
Suman Bala Neha Sharma Anu Kajal Sunil Kamboj Vipin Saini

Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of ...

2013
Natvar A. Sojitra Tarosh S. Patel Ritu B. Dixit Bharat C. Dixit Sardar Patel

Heterocyclic scaffold including nitrogen, sulfur and oxygen has been under exploration due to their significant therapeutic and medicinal properties. Among these types of molecules, 4thiazolidinones have displayed various important biological activities. Especially rhodanine (2-thioxothiazolidine-4-ones) derivatives represent privileged scaffolds in drug discovery, due to the presence of >N–C–S...

Journal: : 2021

Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area study in medical chemistry. They are present variety drugs, vitamins biologically active compounds. Over two decades, 1,3,4-oxadiazoles have interest to chemists owing their diverse therapeutic potential; the studies focus mainly on principles combinatorial chemistry with broad s...

Journal: :Bioorganic & medicinal chemistry letters 2007
Aaron B Bate Jay H Kalin Eric M Fooksman Erica L Amorose Cristofer M Price Heather M Williams Michael J Rodig Miguel O Mitchell Sang Hyun Cho Yuehong Wang Scott G Franzblau

Quaternized chlorpromazine, triflupromazine, and promethazine derivatives were synthesized and examined as antitubercular agents against both actively growing and non-replicating Mycobacterium tuberculosis H37Rv. Impressively, several compounds inhibited non-replicating M. tuberculosis at concentrations equal to or double their MICs against the actively growing strain. All active compounds were...

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