To purchase reprints, contact The InnoVision Group, 101 Columbia, Aliso Viejo, CA 92656. Phone, (800) 8092273 or (949) 362-2050 (ext 532); fax, (949) 362-2049; e-mail, [email protected]. patients given local anesthetics also receive intravenous sedatives such as benzodiazepines to relieve anxiety. One of the main risks of local anesthesia is local toxic effects caused by accidental intravascula...

Patients with type II Alexander disease have white matter dysplasia, which may cause various symptoms due to nerve conduction impairment. When providing anesthesia a patient disease, careful and patient-specific individualized risk evaluation must be preceded by planning the method of anesthetic drugs. This is first case report who underwent general anesthesia. We performed on 45-year-old male ...

their optimal clinical utilization. History and Principles Whereas inhaled anesthetics are useful for the induction of anesthesia, particularly in the absence of IV access as occurs commonly in pediatric anesthesia, IV anesthetics have become the primary agents for the induction of general anesthesia. The development of IV anesthetics followed the late 19th-century introduction of hollow needle...

Correa, Ana M. Gating kinetics of Shaker K1 channels are differentially modified by general anesthetics. Am. J. Physiol. 275 (Cell Physiol. 44): C1009–C1021, 1998.—The ShakerB K1 channel was used as a model voltage-gated channel to probe the interaction of volatile general anesthetics with gating mechanisms. The effects of three anesthetics, chloroform (CHCl3), isoflurane, and halothane, were s...

BACKGROUND Inhibition of voltage-gated Na channels (Na(v)) is implicated in the synaptic actions of volatile anesthetics. We studied the effects of the major halogenated inhaled anesthetics (halothane, isoflurane, sevoflurane, enflurane, and desflurane) on Na(v)1.4, a well-characterized pharmacological model for Na(v) effects. METHODS Na currents (I(Na)) from rat Na(v)1.4 alpha-subunits heter...

BACKGROUND A relatively small number of inhibitory interneurons can control the excitability and synchronization of large numbers of pyramidal cells in hippocampus and other cortical regions. Thus, anesthetic modulation of interneurons could play an important role for the maintenance of anesthesia. The aim of this study was to compare effects produced by volatile anesthetics on inhibitory posts...

Organs needed for transplantation far outweigh their availability. There is minimal research regarding perioperative care of the brain-dead organ donor during the procurement procedure. Current research attributes a great deal of organ damage to autonomic or sympathetic storm that occurs during brain death. Literature searches were performed with the terms brain death, organ donor, organ procur...

The use of anesthesia during nineteenth century was extremely limited due to the hazards of the available anesthetics and the inability to successfully monitor the patient. This resulted in the majority of surgical procedures being performed without any anesthesia (Gordetsky et al, 2011). A revolutionary step in the history of anesthetics began in 1884, when Carl Koller, a scientist from Vienna...

Currently available local anesthetics have analgesic durations in humans generally less than Prolonged-duration local anesthetics will be useful. to the complexities that a case of strabismus may pertain to, it is worthwhile to get to know more about the This brief review -as its name implieddoes not attempt surgery -due to myotoxicity by local anesthetic agent(albeit rare),. This review draws ...

The ShakerB K+ channel was used as a model voltage-gated channel to probe the interaction of volatile general anesthetics with gating mechanisms. The effects of three anesthetics, chloroform (CHCl3), isoflurane, and halothane, were studied using recombinant native and mutant Shaker channels expressed in Xenopus oocytes. Gating currents and macroscopic ionic currents were recorded with the cut-o...