نتایج جستجو برای: anergy

تعداد نتایج: 1795  

2017
Manon Dekeyser Marie-Ghislaine de Goër de Herve Houria Hendel-Chavez Céline Labeyrie David Adams Ghaïdaa Adebs Nasser Jacques Gasnault Antoine Durrbach Yassine Taoufik

Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to central nervous system replication of the human polyomavirus JC virus (JCV) in immunosuppressed patients. The only effective therapeutic approach is to restore anti-JCV T-cell responses. In this study, we describe a case of rapidly fatal PML with JCV T-cell anergy in a renal transplant patient treated with...

Journal: :Clinical immunology 2003
Jonathan D Powell

While the "true" role of T cell anergy in promoting peripheral tolerance continues to be debated, it is clear that studying the various models of anergy have led to important insight in terms of understanding the pathways and molecules responsible for T cell activation and inhibition. This review will examine our current understanding of CD4+ T cell anergy. In particular, it will focus on the s...

Journal: :Journal of immunology 2009
Shunsuke Chikuma Seigo Terawaki Tamon Hayashi Ryusuke Nabeshima Takao Yoshida Shiro Shibayama Taku Okazaki Tasuku Honjo

Accumulating evidence suggests that PD-1, an immuno-inhibitory receptor expressed on activated T cells, regulates peripheral T cell tolerance. In particular, PD-1 is involved in the induction and/or maintenance of T cells' intrinsic unresponsiveness to previously encountered Ags, although the mechanism is yet to be determined. We used a simple experimental model to dissect the mechanism for ane...

Journal: :Cell 2002
Fernando Macián Francisco Garcı́a-Cózar Sin-Hyeog Im Heidi F. Horton Michael C. Byrne Anjana Rao

In lymphocytes, integration of Ca2+ and other signaling pathways results in productive activation, while unopposed Ca2+ signaling leads to tolerance or anergy. We show that the Ca2+-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte function. Ca2+/calcineurin signaling induces a limited set of anergy-associated genes, distinct from genes induced in the produc...

Journal: :Cancer research 1966
M W Chase

given with respect to anergy and its implications, based on pres ent immunologie understanding. The sources of patients and the types of tests are tabulated, the small numbers studied hardly warranting the usual custom of expressing findings as percentages. Comparison is made in several areas, by tabulation of sources with parallel information secured in studies on sarcoidosis, another disease ...

Journal: :Journal of immunology 1999
L C Korb S Mirshahidi K Ramyar A A Sadighi Akha S Sadegh-Nasseri

Engagement of TCR by its ligand, the MHC/peptide complex, causes T cell activation. T cells respond positively to stimulation with agonists, and are inhibited by antagonist MHC/peptide ligands. Failure to induce proper conformational changes in the TCR or fast TCR/MHC dissociation are the leading models proposed to explain anergy induction by antagonist ligands. In this study, we demonstrate th...

Journal: :Journal of immunology 2000
K A Frauwirth M L Alegre C B Thompson

Immunologic tolerance in T lymphocytes is maintained through both thymic and peripheral contributions. One peripheral tolerance mechanism is the induction of T cell anergy, a form of nonresponsiveness resulting from incomplete T cell activation, such as stimulation through the TCR in the absence of costimulation. Recent reports have suggested that engagement of the inhibitory receptor CTLA-4 by...

Journal: :Journal of immunology 2014
Tzu-Sheng Hsu Huey-Wen Hsiao Pei-Jung Wu Wen-Hsien Liu Ming-Zong Lai

The generation of T cell anergy is associated with upregulation of ubiquitin E3 ligases including Casitas B-lineage lymphoma (Cbl-b), Itch, gene related to anergy in lymphocyte, and deltex1 (DTX1). These E3 ligases attenuate T cell activation by targeting to signaling molecules. For example, Cbl-b and Itch promote the degradation of protein kinase Cθ (PKCθ) and phospholipase C-γ1 (PLC-γ1) in an...

Journal: :Journal of immunology 1999
J D Powell C G Lerner R H Schwartz

Costimulation (signal 2) has been proposed to inhibit the induction of T cell clonal anergy by either directly antagonizing negative signals arising from TCR engagement (signal 1) or by synergizing with signal 1 to produce IL-2, which in turn leads to proliferation and dilution of negative regulatory factors. To better define the cellular events that lead to the induction of anergy, we used the...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید