background and objective: alzheimer’s disease (ad) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. with regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of alzheim...

introduction: to study the effect of gallic acid (ga) on hippocampal long-term potentiation (ltp) and histological changes in animal model of alzheimer disease (ad) induced by betaamyloid (aβ). methods: sixty-four adult male wistar rats (300±20 g) were divided into 8 groups: 1) control (cont); 2) ad; 3) sham; 4-7) ad+ga (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) cont+ga100, aβ ...

alzheimer's disease (ad) is considered as the greatest thread to adults aged 65 and older. it stands as the most common cause of dementia, the prevalence of which is around 24 million worldwide. ad is a progressive and degenerative disorder that combats the neurons, leading to impairment of different cognitive functions. ad is characterized by an accumulation of two factors normally presen...

Neurological inflammatory diseases are developing rapidly. Different factors involved in the pathogenesis of these diseases. In this article, we discuss some of the mechanisms are dealt with. An aberrant procedure of beta-amyloid precursor protein (BAPP) to form neurotoxic beta-amyloid peptides and an accumulated insoluble polymer of beta –amyloid (BA) that forms the senile plaque. The ab...

background and objective: alzheimer’s disease (ad) is a neurodegenerative disorder specified by deposition of b-amyloid (ab) and neuronal loss that leads to learning and memory disturbances. one of the most important causes of ad is glutamate-dependent excitotoxicity in brain regions that is vulnerable to ad. according to previous reported results, it was revealed that riluzole, as a glutamate ...

alzheimer’s disease (ad) is a neurodegenerative disease that was characterized with deposit of beta amyloid (aβ) aggregate in senile plaque. oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. melissa officinalis is a medicinal plant from lamiaceae family, used traditionally in the treatment of cognitive disorders. it has cholinomimetic ...

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease and pathologically characterized by the presence of neurofibrillary tangles (tau aggregation) amyloid plaques (amyloid-beta (A

Alzheimer’s disease (AD) is a neurodegenerative disease that is the most common type of dementia.AD includes 60_80% of dementia and most people with AD have more than 65 years old.AD causes losing neuronal activity by abnormal proteins. Plaques of beta-amyloid and tangles of “tau” protein can lead to AD. Recently evidence has found that AD may come from outside of central nerv...

beta-Amyloid peptide produces apoptosis in neurons at micromolar concentrations, but the mechanism by which beta-amyloid exerts its toxic effect is unknown. The normal biological function of beta-amyloid is also unknown. We used phage display, co-precipitation, and mass spectrometry to examine the protein-protein interactions of beta-amyloid in normal rabbit brain in order to identify the bioch...