Rats rendered diabetic by alloxan monohydrate were studied to investigate the effect of increased blood glucose upon the concentration of various putative neurotransmitter amino acids in the cerebellum. No modification was found in the concentrations of glutamate, gamma aminobutyric acid (GABA), glutamine, glycine or taurine, but there was a significant decrease in the cerebellar concentration ...

The present study was carried out to investigate the antihyperglycemic effect of Oxytenanthera abyssinica leaf extract and fractions. Diabetes induced in rats by administering a single dose 150 mg/kg alloxan monohydrate. Single doses 100 200 methanol (Met-E), n-hexane fraction (nHex-F), ethyl-acetate (EA-F) (Met-F) were orally administered diabetic rats. Met-E Met-F selected at 400 mg/kg. plasm...

Based on the hypothesis that consistent hyperglycemia can result in insulin resistance, we explored the induction of non-insulin dependent diabetes mellitus (NIDDM) using diet of high glycemic/low fat index and compared the effects on the physiology and histology of the rats. The rats were divided into 3 groups. DM was induced in the first group by single intraperitoneal injection of 150mg/kg a...

Briscoe, H. Frances (University Medical Center, Jackson, Miss.), and Fred Allison, Jr. Diabetes and host resistance. I. Effect of alloxan diabetes upon the phagocytic and bactericidal efficiency of rat leukocytes for pneumococcus. J. Bacteriol. 90:1537-1541. 1965.-Chronic diabetes mellitus was induced in rats with alloxan monohydrate. Glycosuria persisted for the 6 weeks of study, but ketonuria...

BACKGROUND AND AIM Diabetes mellitus is known to cause neurological disorders due to impaired glucose metabolism involving decreased utilization of glucose by the brain tissues. The mechanisms responsible for failure of glycemic regulation in type-2 diabetes leading to neurological impairment need to be thoroughly elucidated. MATERIALS AND METHODS Type-2 diabetes was induced in albino rat mod...

The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of Plectranthus amboinicus in normal and alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Normal as well as diabetic rats were divided into groups (n=6) receiving different treatment...

objectives: diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver. the aim of this study was to investigate the effects of hydroalcoholic extract of prangos ferulacea (l.) lindle (p.f) on changes in rats´ liver structure and serum activities of alanin and aspartate aminotransferases after alloxan injection. materials and methods: in this study...

Plan: The anti-diabetic and anti-hyperlipidemic effects of D-3-O-methylchiroinositol were investigated in male Wistar rats. Methodology: Diabetes was induced by a single intra-peritoneal injection of 150 mg/kg of alloxan monohydrate. Five groups of rats comprising six animals in each group were used including a positive control group (glibenclamide, 2 mg/kg), treatment groups (8, 4 and 2 mg/kg ...

The study was designed to evaluate the anti-diabetic effect of aqueous extract of Bauhinia tomentosa L. leaf on alloxan induced Wistar albino rats. Diabetes was induced in albino rat models with alloxan monohydrate (150mg/kg body weight). Aqueous leaf extract of Bauhinia tomentosa at the dose of 300 mg/kg was orally administered once a day for 30 days to the diabetic animals. In this study, gly...

Diabetes is a metabolic disease that is affecting major population of developing countries causing deaths. Objectives: The ethanolic root extract of Nauclea latifolia use traditionally for the treatment of diabetes was evaluated for antidiabetic activity in alloxan-induced diabetic rats after a single dose (acute study) and prolonged treatment (chronic study). Materials and Methods: Diabetes wa...