Background and rationale. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease in western countries. Its prevalence in Indian subcontinent is not well studied. MATERIAL AND METHODS In a school based cross sectional study we have screened overweight and obese children in the age group of 11 to 15 years for NAFLD. Ultrasonography, elevated serum transami...

Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional pro...

The study of serum transaminases has recently entered clinical practice. In December, 1954, Wroblewsky and La Due demonstrated an increase of glutamic-oxalacetic (GOT) transaminase in the serum of patients suffering from various liver diseases and in carbon tetrachloride intoxication. In 1955, de Ritis, Coltorti and Giusti demonstrated an increase of both aspartic-ketoglutaric (GOT) and alanine...

The activity of alanine-cr-ketoglutarate transaminase (n-alanine :2-oxoglutarate aminotransferase, EC 2.6.1.2) is increased markedly in the livers of diabetic or fasted rats (1). The induction of this enzyme also occurs when either intact or adrenalectomized rats are fed diets high in protein or given corticosteroid injections (24). The adaptive response of this enzyme in glucocorticoid-sensiti...

The activity of alanine-cr-ketoglutarate transaminase (n-alanine :2-oxoglutarate aminotransferase, EC 2.6.1.2) is increased markedly in the livers of diabetic or fasted rats (1). The induction of this enzyme also occurs when either intact or adrenalectomized rats are fed diets high in protein or given corticosteroid injections (24). The adaptive response of this enzyme in glucocorticoid-sensiti...

introduction valproic acid (vpa, valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. vpa use might lead to mild to severe hepatotoxicity. the aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of vpa treatment and after three and six months of it. materials and methods this study was designed as a cross sectional pro...

1. The metabolism of L-alanine was studied in isolated guinea-pig kidney-cortex tubules. 2. In contrast with previous conclusions of Krebs [(1935) Biochem. J. 29, 1951-1969], glutamine was found to be the main carbon and nitrogenous product of the metabolism of alanine (at 1 and 5 mM). Glutamate and ammonia were only minor products. 3. At neither concentration of alanine was there accumulation ...

The general performance of the Technicon AutoAnalyzer II method for the routine estimation of serum aspartate and alanine transaminase has been assessed and compared with that of the LKB reaction rate analyser. The results of the two methods correlate, there is little difference in precision, and running costs are comparable. Some of the relative advantages of the two types of analysis are disc...

Background: Non-alcoholic Fatty liver disease, also known as NAFLD is said to result from a number of disorders such insulin resistance, Obesity & diabetes mellitus possibly an unhealthy and sedentary life style. The prevalence stated be 25.23%, but it ranges between 115 45% in Asian countries globally. Plasma aminotransferases (aspartate1aminotransferase [AST] alanine aminotransferase [ALT...