Cold agglutinins are autoantibodies that agglutinate red blood cells at low temperatures, leading to haemagglutination and haemolysis. They are generally of no clinical significance. However, when people with cold agglutinins undergo cardiac operation with hypothermia and cold cardioplegia, they can experience complications. Thus, different perioperative management is required for such patients...

background and objective: brucellosis is a zoonotic disease of worldwide distribution and has great economic importance. despite its control in many countries, it remains endemic in iran. brucellosis was investigated in many high risk occupational groups; however, few studies on the prevalence of brucellosis among blood donors are available. to determine the seroprevalence of brucellosis antibo...

The purpose of this report is to describe some investigations which attempt to define the nature and incidence of naturally occurring leucocyte agglutinins. Agglutinins have been demonstrated in the sera of patients with acquired hemolytic anemia (1) and thrombocytopenic purpura (2, 3) and these have been distinguished from naturally occurring anti-red cell (4) and anti-platelet (5) agglutinins...

In a previous communication (Mackie, 1938) we have reported observations upon the Shigella dysenteriae agglutinin curves in a group of patients presenting the intestinal pathology of chronic bacillary dysentery and bacteriologic or serologic evdence of infection by these organisms. Fluctuation of the titre curves in individual patients, the common finding of higher titres in the culture-negativ...

cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (cpb). cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually igm or iga antibodies) that agglutinate in response to a decrease in body temperature. these disorders include cryoglobulinemia and cold hemagglutinin disease.immunoglobulin m aut...

In an attempt to simplify the manufacture of an efficacious antimeningococcus serum an experimental study has been made of a number of sera produced with a few or with single strains of meningococcus, the therapeutic polyvalent serum produced at The Rockefeller Institute with more than 50 strains being used as a standard of comparison. It was found that horses injected with an antigen limited t...

A review of recently published work is presented on the nature of the agglutination of human peripheral lymphocytes and cultured lymphoblastoid cells by the hemolymph agglutinins of two arachnoids, the Horsefoot (Limulus polyphemus), alias Horseshoe Crab, and the Saharan Scorpion (Androctonus australis). Microagglutination techniques were utilized to study the specificity of the whole serum and...

A comparison of the appearance of the agglutinins for Bacillus abortus in the blood of new-born calves with the first appearance of globulins in the same blood following the ingestion of colostrum indicates that the agglutinins are associated with the globulins. These observations are supported by the removal of the agglutinins from serum or colostrum with concentrations of sodium sulfate which...

1. Certain bacilli within one strain may lose their flagella and become non-motile. 2. The change in serological behavior associated with the change in motility indicates that the flagella possess an individual antigenic property. 3. Flagella can be separated from the bodies of the bacilli. 4. A strictly flagellar antiserum can be produced by the injection of a flagellar suspension. 5. This dir...