For pathological high-risk prostate cancer, adjuvant irradiation has shown a survival benefit. Phase III studies have highlighted that half men would face biochemical relapse and would be candidate for radiotherapy at adjuvant or salvage times. Despite at least four published international contouring guidelines from different collaborative groups, discrepancies remain for volumes, delineation, ...

The success of many vaccines relies on their association with selected adjuvants in order to increase their immunogenicity and ensure long-term protection. Propolis is a natural compound, mostly known for its immunostimulatory properties. In this study the adjuvant effects of propolis in combination with formalin-killed Aeromonas hydrophila vaccine in Common carp (Cyprinus carpio) were evaluate...

objective: for immunotherapy of human papillomavirus (hpv) -16-associated cervical cancers the e7 protein is considered a prime candidate. however it is a poor inducer of cytotoxic t-cell response, when being used as a singular antigen in protein vaccination. hence, in this study we focused on the utilization of a vaccine delivery system for prevention or treatment of cervical cancer. materials...

Background Th1/Tr1 promoting adjuvants, in allergen-specific vaccines, could be a valuable alternative to the current allergen immunotherapy. It is now the pro-Th1 adjuvant effect of Neisseria meningitidis proteoliposome (PL). Previous studies in a prophylactic murine model of respiratory allergy the vaccine showed its immunogenicity and safety. To assess the immunogenicity and non-clinical saf...

echinococcosis is one of the world’s relevant zoonoses, affecting both humans and their domestic animals and caused by infection with the metacestode stage of the dog tapeworm, echinococcus granulosus. in the present study, twenty mice were randomly divided into 4 groups of 5. each mouse in groups 1, 2 and 3 was immunized with 100 μg of hydatid cyst fluid protein, protoscolex and adult worms of...

Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all five congenic mouse strains responded to several transmissio...

The success of many vaccines relies on their association with selected adjuvants in order to increase their immunogenicity and ensure long-term protection. Propolis is a natural compounds, are mostly known for their immunostimulatory  properties. In this study the adjuvant effects of propolis in combination with formalin-killed A. hydrophila vaccine in Common carp (Cyprinus carpio) were evaluat...

BACKGROUND A candidate pandemic influenza H5N1 vaccine should provide rapid and long-lasting immunity against antigenically drifted viruses. As H5N1 viruses are poorly immunogenic, this may require a combination of immune potentiating strategies. An attractive approach is combining the intrinsic immunogenicity of virosomes with another promising adjuvant to further boost the immune response. As...