Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic protein exclusively expressed in brown adipocytes, the beige adipocytes have a gene expression pattern distinct from that of brown adipocytes. Howev...

Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin. White adipocytes respond to adrenergic stimuli by enhancing lipolysis, while in beige adipocytes adrenalin induces mitochondrial biogenesis too. A key step in the ...

Adipocyte tissue inflammation orchestrates the occurrence and development of diseases induced by obesity. Here, effects Lagerstroemia speciosa (L.) Pers total flavonoids (LTF) on TNF-α-induced insulin resistance (IR) inflammatory response in 3T3-L1 adipocytes underlying mechanisms were studied. Cell glucose uptake test confirmed that TNF-α could induce IR adipocytes. The sensitivity to was incr...

background: the modern dairy cows, due to intensive selection for higher milk production during past decades, have become more resistant to insulin. accompanied with dmi depression in per parturient dairy cow, insulin resistance may lead to a massive release of non-esterified fatty acids (nefa) to bloodstream which might act as a start point for development of other diseases. objectives: the pu...

Abstract The presence of subcutaneous adipose tissue in excess on a carcass can significantly contribute to financial losses for the producer and processor. Technology with potential limit this accumulation could provide another avenue improve animal efficiency. Stearoyl-CoA desaturase 1 (SCD1) has been identified as genetic target, it seems tohave crucial role fatty acid metabolism. MiR-199a-3...

The obesity due to high caloric ingestion is related the accumulation of body fat andpredisposes cardiovascular diseases. Recent studies about High Intensity Interval Training(HIIT) evidence benefits its practice in patients that maybe carrying this disease, mainlybecause reduction comorbidities associated with obesity. This present study has theobjective evaluating HIIT effects on adipocytes’ ...

The presence of glycogen in the brown adipose tissue (BAT) has been described 60 years ago. However, role this energetic storage adipocytes long time underestimated. We have recently shown that during adipocyte differentiation embryo, accumulates and is degraded by glycophagy, a dynamic essential for lipid droplets biogenesis. Recent studies degradation triglycerides BAT are not activation resp...

White adipose tissue and brown adipose tissue play critical roles in controlling energy homeostasis and the development of obesity and diabetes. We isolated mouse white adipocytes from inguinal white fat tissues and brown adipocytes from interscapular brown fat tissues, and employed a variety of approaches, including immunofluorescent staining, quantitative real-time PCR, western blotting analy...

l-Theanine is a nonprotein amino acid with much beneficial efficacy. We found that intraperitoneal treatment of the mice l-theanine (100 mg/kg/day) enhanced adaptive thermogenesis and induced browning inguinal white adipose tissue (iWAT) elevated expression Prdm16, Ucp1, other thermogenic genes. Meanwhile, administration increased energy expenditure. In vitro studies indicated development brown...