background: acute promyelocytic leukemia is a sub-type of acute myelogenous leukemia that occurs in about 10-15% of patients with aml. approximately 20%-30% of these patients, who are treated with the current standard all trans retinoic acid (atra) and anthracyclin-based chemotherapy regimen, suffer relapse in less than a year. arsenic trioxide (ato) as a single agent can induce complete remiss...

background: acute promyelocytic leukemia (apl) is a unique subtype of acute leukemia. apl is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in apl patient management. one issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. materials and methods: in ...

A 45-year-old woman presented with sudden severe excruciating headache. Medical history disclosed intermittent fever and weight loss in the past 3 months. No focal neurological deficits were seen. CT scan disclosed diffuse subarachnoid hemorrhage. Cranial CT angiography showed no intracranial aneurysms (Figure). Laboratory evaluation disclosed thrombocytopenia, anemia and abnormalities of white...

Figure 1. Leukemic cell morphology of bone marrow aspiration specimen (May-Grünwald-Giemsa). An 82-year-old woman was admitted to our hospital presenting with febrile neutropenia. She had been diagnosed with chronic myeloid leukemia 2 years ago and had been on imatinib treatment since [1]. A month before admission she presented with malaise, anemia, and mild leukopenia; a bone marrow aspirate a...

Case Presentation The patient was a previously healthy 20-year-old woman who presented with blurred vision, abdominal pain and dizziness following hemorrhoid surgery. Physical examination revealed pallor, wide peripapillary retinal hemorrhage and splenomegaly. Blood examination on admission revealed: WBC; 54×109/μl, Hb;7 gr/dl and Platelet count;16×109/μl, LDH; 3300 IU/L (normal range up to 480...

introduction: acute promyelocytic leukemia treatment revolutionized by new tretamnets. currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited. here we report our experience with stem cell transplantation in acute promyelocytic leukemia patients. design and setting: retrospective, single center methods: between year ...

Avgerinou and coauthors describe a case of cytogenetically cryptic fish-negative acute promyelocytic leukemia (APL) which was finally detected by RT-PCR. The authors highlight the importance of...

Background & Objective:  Zataria multiflora is a plant that belongs to Laminaceae family. It is traditionally believed to have several therapeutic effects. Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with dominancy of promyelocytes in bone marrow and blood stream. The aim of this study is to investigate the anticancer effects of Z. multiflora extract on acute pr...

Dysregulated expression of miRNAs can play a vital role in pathogenesis of leukemia. The shortened telomere length, and elevated telomerase activity in acute promyelocytic leukemia cells are mainly indicative of extensive proliferative activity. This study aimed to investigate the effect of overexpression of miR-138 on telomerase activity, and cell proliferation of acute promyelocytic leukemia ...