نتایج جستجو برای: actin gene
تعداد نتایج: 1174543 فیلتر نتایج به سال:
Background: Alpha-actinins are located in the skeletal muscle Z-line and form actin–actin cross-links. It belongs to a highly conserved family of actin-binding proteins- the spectrin superfamily, which also contains the spectrins and dystrophin. Mammalian skeletal muscle has two isoforms: alpha-actinins-2 and alpha-actinins-3. However, the response of alpha-actinins to exercise training is litt...
the present study was conducted to find the effect of three heavy metals, ag, hg and pb on the expression level of a gene encoding plasma membrane h+-atpase in aeluropus littoralis. the experiment was laid out in a completely random design with three replications. the expression of the main gene was normalized to the expression of the housekeeping gene actin. two 259 and 187 bp fragments were a...
The present study was conducted to find the effect of three heavy metals, Ag, Hg and Pb on the expression level of a gene encoding plasma membrane H+-ATPase in Aeluropus littoralis. The experiment was laid out in a completely random design with three replications. The expression of the main gene was normalized to the expression of the housekeeping gene actin. Two 259 and 187 bp fragments were a...
Abstract BACKGROUND Altered expression of actin subunits is found in multiple cancers. Alpha-cardiac (ACTC1) expressed sonic hedgehog medulloblastoma (SHH MB) and regulates both cell survival migration. We hypothesized that cardiac has a unique structural functional role SHH MB may be post-natal granule progenitors (GCPs) which share similar gene profiles. METHODS Actin subunit protein (ACTC1, ...
Background and Objectives: MutL homolog (MLH1) is a key component of heterodimeric complex MutLα, which recognizes and repairs base-base mismatches or insertion/deletion loops that arise from nucleotide misincorporation. In the absence of MLH1 protein, the number of unrepaired mismatches will increase and cause tumors in organs. The present study aimed at quantitative analysis of MLH1 gene expr...
Background and Objective: Human embryonic stem cells (hESCs) can differentiate in vitro into spontaneously contracting cardiomyocytes and produce a model to investigate the early developmental stages of this system. After removing of cells from their feeder layer, hESCs create embryoid bodies (EB). Plating of EB results in developing areas of beating cells. In the present study, cardiomyocyte g...
background: it has been previously demonstrated that her-2 (human epidermal growth factor receptor 2) positive breast cancers are associated with an aggressive nature. villin is an actin bundling protein that plays a key role in actin reorganization and cell remodeling during stress. in this study, we aimed to investigate the correlation of villin gene expression with her-2 in breast cancer pat...
A protein kinase domain, a Rhodanase-like and the Tre-2/Bub2/Cdc16 (TBC) domain are all encoded by TBCK gene. By modulating mammalian target of rapamycin (mTOR) signaling pathway, is hypothesized to play role in actin organization, cell growth, proliferation. Has organization cytoskeleton.
سرطان مری، یکی از تهاجمی¬ترین نوع سرطان دستگاه گوارش، شایع ترین علت مرگ و میر های مرتبط با سرطان درجهان است. بیشترین بروز سرطان مری در گروه سنی 70-50 سال رخ می دهد. همچنین فراوانی این بیماری در مردان بیشتر از زنان است. تحقیقات مختلف اثبات کرده است که آنکوژن astrocyte elevated gene-1 (aeg-1)، که همچنین mtdh و lyric نیز نامیده می¬شود) در چندین جنبه از پیشرفت تومور نقش اساسی بازی می¬کند. بیان یا ت...
introduction: deficiency in mu opioid receptor signaling pathway is partially responsible for morphine tolerance. this deficiency may be due to uncoupling of opioid receptors and related g proteins, which in turn, it may be caused by their structural changes such as phosphorylation or by decreasing their abundance. in this study, we tried to investigate the effect of chronic administration of m...
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