OBJECTIVES To compare the cortisol response of the 1 μg and the 250 μg ACTH test in a large study of patients with suspected adrenal insufficiency. DESIGN Retrospective cohort study. METHODS Single center study assessing patients tested for primary or secondary adrenal insufficiency between January 2004 and December 2007, who had both ACTH tests (1 μg and 250 μg; n=207) within a time interv...

cases at intervals of 2,3 davs showed the following results : Results -50% and above (+), and -49% or less (-) a) 22 cases of uniform results (59.5%) (-) in both tests ........................... 5 (+) in both tests ........................... 17 b) 15 cases of discrepant results (40.5%) (+) in ACTH test and (-) in epinephrine test......... 2 (-) in ACTH test and (+) in epinephrine test...........

precocious pubarche (pp) is most often a benign condition secondary to the early appearance of adrenarche. however, pp may be a manifestation of mild errors of steroidogenesis in particular non classic 21 hydroxylase deficiency (nc210hd). the incidence of nc210hd in patients with pp ranges from about 0-30% of cases in various reports. controversy exists as to whether all children with pp should...

OBJECTIVE To identify the incidence of secondary adrenal insufficiency in severe sepsis. DESIGN Prospective clinical trial testing 100 patients with a 250-microg adrenocorticotropic hormone (ACTH) stimulation test. SETTING County-university teaching hospital. PATIENTS One hundred patients with sepsis and septic shock. Forty patients had bacteremia and 17% shock. INTERVENTIONS ACTH, cort...

BACKGROUND In earlier work, it was shown that patients with septic shock who also have adrenal insufficiency experience a benefit in terms of lower mortality rates with hydrocortisone supplementation. As such, the adrenocorticotropic hormone (ACTH) stimulation test has been used frequently to identify these patients. However, recent evidence has suggested that the identification and treatment o...

OBJECTIVE Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate the influence of an ACTH receptor promoter polymorphism affecting ACTH receptor...

The adrenocortical response to the simple 30-minute ACTH stimulation test was compared with the hypothalamic-pituitary-adrenocortical (HPA) response to insulin-induced hypoglycaemia in 25 patients with various degrees of hypothalamic-pituitary malfunction. The correlations between the increase in plasma cortisol during insulin hypoglycaemia and that during ACTH stimulation (r = 0-66) and betwee...

The ACTH stimulation test will identify ~50-60 % of dogs with adrenal cortical tumors and ~85 % of dogs with pituitary dependent hyperadrenocorticism (PDH). Therefore, it is a good screening test if positive, but a negative result does not rule out hyperadrenocorticism. Of the screening tests for hyperadrenocorticism in dogs, the ACTH stimulation test had the highest specificity and thus the fe...

A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone-corticotropin releasing hormone; DEX-CRH) or psychosocial stress induction on hypothalamic–pituitary–adrenocortical axis by Trier Social Stress Test (TSST). However, magnitude related to stressors and interaction responsiveness between two tests is still ...

Early embryonic development may be affected by adrenal hyperactivity in stressful situations which lead to endocrine changes the embryo environment. A sensitive period porcine is 4-cell stage when genome activation occurs. mixed vivo-in vitro system was implemented test whether an altered milieu around this could affect and blastocyst quality model. After maturation fertilisation, presumptive z...