OBJECTIVE To investigate heart rate characteristics in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine. DESIGN Clinical trial. ANIMALS 43 client-owned dogs. PROCEDURE 24-hour ambulatory electrocardiography was performed beginning approximately 1 hour prior to administration of premedications. Dogs were premedicated with medetomidine and butorph...

A fatality due to ingestion of zolpidem, a recently developed nonbenzodiazepine hypnotic, and acepromazine, a phenothiazine sedative used in veterinary practice, is reported. Both drugs were identified and quantified using high-performance liquid chromatography with diode-array detection. Zolpidem and acepromazine blood concentrations were 3.29 and 2.40 micrograms/ml, respectively. It is the fi...

Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the acti...

The aim of this study was to investigate the sedative and antinociceptive effects of three dopaminergic blockers often used in veterinary medicine. The study was conducted on 10 Thoroughbred mares. Sedation was evaluated by determining the spontaneous locomotor activity (SLA) in automated individual behavior stalls and by measuring head ptosis (HP). The intravenous injection of acepromazine (0....

The sedative and selected cardiopulmonary effects of acepromazine alone or in combination with methadone, morphine, or tramadol were compared in sheep. Six ewes were randomly assigned to treatments: A (0.05 mg/kg acepromazine), AM (A plus 0.5 mg/kg methadone), AMO (A plus 0.5 mg/kg morphine), and AT (A plus 5 mg/kg tramadol). Parameters were assessed before sedative drug administration (baselin...

Nowadays, because of increasing employment of swine for experimental studies and medical training, it is hopeful to investigate novel and effective anaesthetic protocols for preserving the animal welfare in medical investigation and concurrently improving the quality of research. Therefore, the aim of this study was to investigate a novel and effective anaesthetic protocol in swine undergoing m...

Seventy seven adult large mixed breed dogs of either sex were included in this study. The animals were randomly divided into four groups and received the following drug combinations intramuscularly: Group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), Group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), Group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and Group 4 xylazin...

The aim of this study was to evaluate the effect of a short-acting neuroleptic (acepromazine) on the stress response to transport in roe deer (Capreolus capreolus). Twenty-one roe deer were submitted to a nine-hour road journey to reintroduce and restock this species into Catalonia (north-eastern Spain). The animals were divided into two groups: animals in the treatment group received an intram...