نتایج جستجو برای: 89 mutation
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BACKGROUND KRAS, BRAF and PIK3CA mutations are frequently observed in colorectal cancer (CRC). In particular, KRAS mutations are strong predictors for clinical outcomes of EGFR-targeted treatments such as cetuximab and panitumumab in metastatic colorectal cancer (mCRC). For mutation analysis, the current methods are time-consuming, and not readily available to all oncologists and pathologists. ...
glucose-6-phosphate dehydrogenase (g6pd) is a cytosolic enzyme which its main function is to produce nadph in the red blood cells by controlling the step from glucose-6-phosphate to 6-phospho gluconate in the pentose phosphate pathway. g6pd deficiency is the most common x-chromosome linked hereditary enzymopathy in the world, that result in reduced enzyme activity and more than 125 different mu...
Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic has been a matter of debate. However, the recent finding of frequent BRAFV600E mutations in LCH argues for the latter. The exact cell type that harbors the mutation and is responsible for proliferation remains to be identified. We here a...
The complete sequence of steps of a tentative catalytic cycle for intramolecular hydroamination/cyclisation (IHC) of 4,5-hexadien-1-ylamine (1) by a prototypical cationic [Cp(2)ZrCH(3)](+) zirconocene precatalyst (2) has been examined by employing a gradient-corrected DFT method. The predicted smooth overall reaction energy profile is consistent with the available experimental data, thereby pro...
This paper presents a fine-grained parallel genetic algorithm with mutation rate as a control parameter. The function of the mutation rate is similar to the function of temperature parameter in the simulated annealing [Lundy’86, Otten’89, and Romeo’85]. The parallel genetic algorithm presented here is based on a Markov chain [Kemeny’60] model. It has been proved that fine-grained parallel genet...
This report describes an 89-year-old woman diagnosed with Philadelphia positive Chronic Myeloid Leukemia in 2007 who was initially treated with 200 mg/day imatinib. The patient demonstrated complete molecular response (CMR) in two tests in 2015 and 2018. During treatment between 2007 and 2019, despite increased dosage of imatinib and switching her therapy to nilotinib, complete hematological r...
Error Thresholds and Their Relation to Optimal Mutation Rates p. 54 Are Artificial Mutation Biases Unnatural? p. 64 Evolving Mutation Rates for the Self-Optimisation of Genetic Algorithms p. 74 Statistical Reasoning Strategies in the Pursuit and Evasion Domain p. 79 An Evolutionary Method Using Crossover in a Food Chain Simulation p. 89 On Self-Reproduction and Evolvability p. 94 Some Technique...
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