نتایج جستجو برای: 7 receptor alpha multiple sclerosis

تعداد نتایج: 2036610  

Journal: :iranian journal of immunology 0
alireza andalib immunology department hassan doulabi immunology department mohammadreza najafi neurology department, isfahan medical school mehdi tazhibi biostatic department, isfahan university of medicalsciences, isfahan, iran

background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure c...

Journal: :Medical hypotheses 2004
A P Friedman

Hyporesponsive genetic variants of the melanocortin 1 receptor result in pigmentary phenotypes exhibiting light skin and light color hair, including red hair. These variants are common in populations with high rates of multiple sclerosis, while rare in populations with low rates. Alpha-melanocyte stimulating hormone, the major ligand for this receptor, is responsible for phenotype determination...

Journal: :The New England journal of medicine 2007
David A Hafler Alastair Compston Stephen Sawcer Eric S Lander Mark J Daly Philip L De Jager Paul I W de Bakker Stacey B Gabriel Daniel B Mirel Adrian J Ivinson Margaret A Pericak-Vance Simon G Gregory John D Rioux Jacob L McCauley Jonathan L Haines Lisa F Barcellos Bruce Cree Jorge R Oksenberg Stephen L Hauser

BACKGROUND Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. METHODS We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication,...

2015
Mehrdad Sadeghi Haj Abbas Nikravesh Majid Pahlevan Kakhki Nahid Rakhshi

OBJECTIVES Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-7 receptor alpha chain (IL-7Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are tryin...

Mohammad Reza Khojasteh, Mokhtar Ahmadi, Pouya Ghaderi,

P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...

Journal: :iranian journal of basic medical sciences 0
haikuo xue department of clinical laboratory, the first affiliated hospital of zhengzhou university, zhengzhou 450002, china key clinical laboratory medicine of henan province, zhengzhou 450002, china department of laboratory medicine, zhengzhou university, zhengzhou, henan 450002, china huijun ren department of clinical laboratory, the first affiliated hospital of zhengzhou university, zhengzhou 450002, china key clinical laboratory medicine of henan province, zhengzhou 450002, china lei zhang department of clinical laboratory, the first affiliated hospital of zhengzhou university, zhengzhou 450002, china

objective(s): multiple sclerosis (ms) is a serious neurological autoimmune disease, it commonly affects young adults. vitamin e (vit e) is an important component of human diet with antioxidant activity, which protects the body’s biological systems. in order to assess the effect of vit e treatment on this autoimmune disease, we established experimental autoimmune encephalomyelitis (eae), the ani...

Journal: :jentashapir journal of health research 0
shahnaz mohammadi department of psychology, kharazmi university, tehran, ir iran maryam izadi-mazidi department of psychology, department of psychology, shahed university, tehran, ir iran; department of psychology, shahid chamran university, ahvaz, ir iran. tel: +98-9171346040 negin kazemi department of psychology, kharazmi university, tehran, ir iran

conclusions our study suggests that the personality traits of patients with ms and healthy individuals are not significantly different. patients with ms are likely to use the same coping strategies as healthy individuals, except in the subscale of distancing. results no significant differences in personality characteristics were observed between patients and healthy controls (all p > 0.05). onl...

Journal: :تحقیقات علوم رفتاری 0
فرهاد تنهای رشوانلو علی اکبر سلیمانیان farhad tanhaye reshvanlo ali akbar soleimanian

abstract aim and background: the purpose of the present study was to examine the psychometric properties of multiple sclerosis self-efficacy scale (msss) in a sample population of iranian patients. methods and materials: this research is a descriptive-correlational study with a population of patients afflicted with ms from north khorasan and hamedan provinces. a number of 120 patients, who had ...

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