نتایج جستجو برای: 371 h 980

تعداد نتایج: 537095  

2012
D. Wang L. M. Hamm A. J. Giuffre T. Echigo J. Donald Rimstidt J. J. De Yoreo J. Grotzinger P. M. Dove

The carbonate sedimentary record contains diverse compositions and textures that reflect the evolution of oceans and atmospheres through geological time. Efforts to reconstruct paleoenvironmental conditions from these deposits continue to be hindered by the need for process-based models that can explain observed shifts in carbonate chemistry and form. Traditional interpretations assume minerals...

2012
W. Al-Sawai B. Barbiellini Y. Sakurai M. Itou P. E. Mijnarends R. S. Markiewicz S. Kaprzyk S. Wakimoto M. Fujita S. Basak H. Lin Yung Jui Wang S. W. H. Eijt H. Schut K. Yamada A. Bansil

W. Al-Sawai,1 B. Barbiellini,1 Y. Sakurai,2 M. Itou,2 P. E. Mijnarends,1,3 R. S. Markiewicz,1 S. Kaprzyk,1,4 S. Wakimoto,5 M. Fujita,6 S. Basak,1 H. Lin,1 Yung Jui Wang,1 S. W. H. Eijt,3 H. Schut,3 K. Yamada,6,7 and A. Bansil1 1Department of Physics, Northeastern University, Boston, Massachusetts 02115, USA 2Japan Synchrotron Radiation Research Institute (JASRI), SPring-8, 1-1-1 Kouto, Sayo, Hy...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Jure Acimovic Tina Korosec Matej Seliskar Ingemar Bjorkhem Katalin Monostory Pal Szabo Jean-Marc Pascussi Ales Belic Uros Urleb Darko Kocjan Damjana Rozman

Novel potential inhibitors of the postsqualene portion of cholesterol synthesis were screened in HepG2 cells. 2-(4-Phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol (LK-980) was identified as a prospective compound and was characterized further in cultures of human primary hepatocytes from seven donors. In vitro kinetic measurements show that the half-life of LK-980 is at least 4.3 h. LK-980 do...

2010
Jure Ačimovič Tina Korošec Matej Seliškar Ingemar Bjorkhem Katalin Monostory Pal Szabo Jean-Marc Pascussi Ales Belič Uroš Urleb Darko Kocjan Damjana Rozman

Novel potential inhibitors of the postsqualene portion of cholesterol synthesis were screened in HepG2 cells. 2-(4-Phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol (LK-980) was identified as a prospective compound and was characterized further in cultures of human primary hepatocytes from seven donors. In vitro kinetic measurements show that the half-life of LK-980 is at least 4.3 h. LK-980 do...

Journal: :EPJ Web of Conferences 2019

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