The high incidence of breast cancer observed in young African-American women (7) and the apparent aggressiveness of the disease in this ethnic group (2) might be because of biologic differences, such as genetic susceptibility to environmental factors and/or hormonal levels. We have recently shown (3) that a polymorphism in the CYP1 Al gene, which is involved in estrogen metabolism, is significa...

Pentobarbitone-induced hypnosis test was used as an animal model to explore the role of BR-16A, a polyherbal formulation in sleep. Pentobarbitone produces quick sleep latency (onset) and prolongation of total sleep time (duration). Sleep latency and total sleep time were used as a parameters for the evaluation. BR-16A potentiated the effect of triazolam (0.1 mg/kg, ip) and alprazolam (0.25 mg/k...

The aim of the present study was to investigate the sleep promoting effect of BR-16A, a polyherbal formulation along with GABAergic drugs. Pentobarbitone-induced hypnosis test was used as an animal model to explore its role in sleep. Pentobarbitone produces quick the sleep latency (onset) and prolongation of total sleep time (duration). Seep latency and total sleep time were used as parameters ...

The aim of the present study was to investigate the sleep promoting effect of BR-16A, a polyherbal formulation along with GABAergic drugs. Pentobarbitone-induced hypnosis test was used as an animal model to explore its role in sleep. Pentobarbitone produces quick the sleep latency (onset) and prolongation of total sleep time (duration). Seep latency and total sleep time were used as parameters ...

Arylidenemalononitriles, 2-Cyano-1,1 -diaminoethene, Arylhydrazones, s_y«-2-Pyridinealdoxime, Pyridines Reactions of arylidenemalononitriles la-d with 2-cyano-l,l-diaminoethene (5); arylhydra­ zones 14a,b and syn-2-pyridinealdoxime 15 afforded the title derivatives 3a-d; 16a,b and 17, respectively. Bipyridyl derivatives 11-13 were also synthesized. Unambiguous syntheses and/ or spectral analyse...

Repeated administration of pentylenetetrazol (PTZ 30 mg/kg, thrice a week) to mice for 9 weeks and subsequent challenge of the animals with the same dose of PTZ on the last chronic dose produced chemical kindling. The mice showed myoclonic jerks, clonus, Straub’s tail, falling back response and full-blown convulsions. The anticonvulsant profile of chronic administration of BR16A (100 and 500 mg...

BR-16A is a herbal preparation with several putative psychotropic effects. Recent work has suggested that it facilities certain aspects of cognition and that it ameliorates ECT-induced amnesia in animal models. The present study sought to assess whether it affects noradrenergic and dopaminergic functioning in the central nervous system. Adult male Sprague-Dawley rats received BR-16A (200mg/kg) ...

A series of novel aryl-2H-pyrazole derivatives bearing 1,4-benzodioxan or 1,3-benzodioxole moiety were designed as potential telomerase inhibitors to enhance the ability of aryl-2H-pyrazole derivatives to inhibit telomerase, a target of anticancer. The telomerase inhibition tests showed that compound 16A displayed the most potent inhibitory activity with IC(50) value of 0.9 μM for telomerase. T...

Previously unknown 1,1,4-tris(trimethylsilyl)-4-acyldodecamethylcyclohexasilanes (Me3Si)2Si6Me12(Me3Si)COR (16a, R = tert-butyl; 16b, R = 1-adamantyl) have been synthesized by the reaction of the potassium silanides (Me3Si)2Si6Me12(Me3Si)K with acid chlorides ClCOR, and their photochemical rearrangement reactions have been studied. The molecular structures of 16a,b as determined by single-cryst...

Moffatt oxidation of 2',3'-O-isopropylideneuridine (1a) and treatment of the crude 5'-aldehyde with formylmethylene-stabilized Wittig reagent gave the vinylogously extended 7'-aldehyde2a. Condensation of 2a with ethoxycarbonyl- or dibromomethylene phosphorane reagents gave the conjugated dienes 6a and 4a, respectively. Deacetonization gave diene ester 7a [5'(E),7'(E); with s-trans conformation]...