Heptageniid mayfly nymphs have been suggested as sensitive indicators of metal contamination in streams based on biomonitoring studies, experimentation in situ, and experimentation in microcosm. Laboratory tests were conducted to evaluate the sensitivity of Rhithrogena hageni, a heptageniid mayfly, to waterborne copper, cadmium, and zinc. Tests were conducted with soft water (hardness = 40-50 m...

Bank voles free living in a contaminated environment are known to be more sensitive to cadmium (Cd) toxicity than the rodents exposed to Cd under laboratory conditions, but the reasons for this difference are poorly defined. The present work was designed to determine whether dietary lead (Pb), a common environmental co-contaminant, and/or animal density that affects various physiological proces...

Anchovy oil is a very suitable supplementary ingredient for fish feeds due to the essential fatty acid composition. The acute toxicity of zinc and copper ions for rainbow trout (Oncorhynchus mykiss Walbaum 1792) were evaluated by static bioassays. The average weight and lenght of fish used in the zinc experiments were 3,02 ±0.21 g and 6.52 ±0.12 cm, respectively, while the tests with copper ion...

Injectable zinc, a vital component of parenteral nutrition (PN) formulations, has been in short supply in the United States since late 2012. In December 2012, three premature infants with cholestasis hospitalized in Washington, DC, experienced erosive dermatitis in the diaper area and blisters on their extremities, a condition that can be associated with zinc deficiency. All three infants were ...

Despite evidence of contamination in Antarctic coastal marine environments, no water-quality guidelines have been established for the region because of a paucity of biological effects data for local Antarctic species. Currently, there is limited information on the sensitivity of Antarctic microalgae to metal contamination, which is exacerbated by the lack of standard toxicity testing protocols ...

Stormwater discharges from Chollas Creek, a tributary of San Diego Bay, have been shown to be toxic to aquatic life. The primary objective of this study was to provide the linkage between in-channel measurements and potential impairments in the receiving waters of San Diego Bay. This study addressed this objective within the context of four questions: (1) How much area in San Diego Bay is affec...

Evidence for an RNA gain-of-function toxicity has now been provided for an increasing number of human pathologies. Myotonic dystrophies (DM) belong to a class of RNA-dominant diseases that result from RNA repeat expansion toxicity. Specifically, DM of type 1 (DM1), is caused by an expansion of CUG repeats in the 3'UTR of the DMPK protein kinase mRNA, while DM of type 2 (DM2) is linked to an exp...