The State of Bhurtpoor, in common with, the surrounding districts, had been free from small-pox for nearly four years, when the present outbreak began. Having no data to go upon, I shall not speculate on the origin of the epidemic. Some of the first cases were in famine-stricken refugees from Bikanir and Marwar, and the disease had appeared in Agra a full month before these were noted; but its ...

The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral infections have been less successful than those targeting bacterial infections. While bacteria commonly reproduce themselves outside of cells ...

We designed and engineered a non-infectious Biothreat simulant that included the nucleic acid signature of Bacillus anthracis, Yersinia pestis, Coxiellla Burneti, Brucella sp., Francicella tularensis, Entherohemorragic E. coli, O157:H7, Burkholderia mallei, Burkholderia pseudomallei and Variola virus (smallpox virus). A chimera of 2040 bp was engineered to produce PCR amplicons of different siz...