The amino acid glycine is involved not only in protein formation but in t,he synthesis of glutathione, creatine (l), and the protoporphyrin of hemoglobin (2). However, the mechanism by which the animal organism forms glycine is cluite obscure. It has been generally considered that the “nonessential” amino acids are synthesized from a-keto acids either by amination with ammonia or by transaminat...

Various ester and thioester derivatives of hippuric acid have been prepared which were substrates of both beta-lactamases and DD-peptidases. The thioesters were more rapidly hydrolysed by nearly all the enzymes. Surprisingly, the enzymes acted rather efficiently on substrates which did not contain any chiral centre.

The amino acid glycine is involved not only in protein formation but in t,he synthesis of glutathione, creatine (l), and the protoporphyrin of hemoglobin (2). However, the mechanism by which the animal organism forms glycine is cluite obscure. It has been generally considered that the “nonessential” amino acids are synthesized from a-keto acids either by amination with ammonia or by transaminat...

Recent evidence suggests that metabolic changes play a pivotal role in the biology of cancer and in particular renal cell carcinoma (RCC). Here, a global metabolite profiling approach was applied to characterize the metabolite pool of RCC and normal renal tissue. Advanced decision tree models were applied to characterize the metabolic signature of RCC and to explore features of metastasized tum...

Previously we showed that feeding polyphenol-rich wild blueberries to hypertensive rats lowered systolic blood pressure. Since probiotic bacteria produce bioactive metabolites from berry polyphenols that enhance the health benefits of berry consumption, we hypothesized that adding probiotics to a blueberry-enriched diet would augment the anti-hypertensive effects of blueberry consumption. Group...

Toluene is known to be the most popular solvent for industrial use,1,2) and attention has been paid on the possibility of biological monitoring of toluene exposure by urinalysis for metabolites such as hippuric acid and o-creso1.3-5) In a previous study6) on possible ethnic difference in toluene metabolism, it was disclosed that Chinese toluene workers excrete less hippuric acid in urine than t...

I. The interaction between nitrogen and water intake was studied in two ewes and two red deer hinds. They were given pelleted diets, at maintenance level, containing equal amounts of roughage but either rich or poor in nitrogen. The deer received 5 0 yo more food than the sheep. Water was given either in large amounts (sheep 5.0 1, deer 7.0 1 daily) or in small amounts (sheep 1.1 1, deer 2.4 1 ...

PETTENKOFERFATHER OF EXPERIMENTAL HYGIENE Max Von Pettenkoffer (1818-1901) studied at the University of Munich and obtained his M.D. He undertook postgraduate studies in chemistry at Wurzberg, where he identified hippuric acid in the urine and described a qualitative test for bile saltsthe Pettenkoffer’s test. In 1847, he was called to Munich, as Professor of medical chemistry, a newly created ...

Studies are presented on the isolation, localization, and characterization of hippuricase activity of group B streptococci. Washed, intact cells, live or heat killed at 56 C, exhibited hydrolysis of hippuric acid, but cell-free filtrates of the organism did not. Excellent hippuricase activity was recoverable from supernatant fluids of mechanically disrupted cells, and evidence suggests that it ...