improvement in braking performance and vehicle stability can be achieved through the use of braking systems whose brake force distribution is variable. electronic braking force distribution has an important and serious role in the vehicle stopping distance and stability. in this paper a new approach will be presented to achieve the braking force distribution strategy for articulated vehicles. f...

Abstract L-type amino acid transporter 2 (LAT2) is a Na + -independent neutral transporter, whose function regulation system remains unclarified. Since protein kinase C (PKC) known to regulate the functions of various transporters, we investigated whether human LAT2 (hLAT2) regulated by PKC. In mouse proximal tubule S2 cells, hLAT2 transport activity was upregulated PKC activation. However, fou...

The single vehicle routing problem with multiple routes is a variant of the vehicle routing problem where the vehicle can be dispatched to several routes during its workday to serve a number of customers. In this paper we propose a goal programming model for multi-objective single vehicle routing problem with time windows and multiple routes. To solve the model, we present a heuristic method wh...

Abstract Carbamazepine (CBZ) is the first-line anticonvulsant drug with a narrow therapeutic index (NTI) and substrate for CYP3A4 MRP-2. Ajuga bracteosa (AB), family Lamiaceae widely used to treat epilepsy, gastric diseases, protects against liver damage in folk. It contains bioactive metabolites, which are powerful inhibitors of CYP3A4, CYP3A5, CYP19, CYP2C19 enzymes P-gp transporter. Concomit...

Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. The present study aimed to investigate the analgesic effect of the specific sodium-p...

Astrocytes serve essential roles in human brain function and diseases. Growing evidence indicates that astrocytes are central players of the feedback modulation excitatory Glu signalling during epileptiform activity via Glu-GABA exchange. The underlying mechanism results increase tonic inhibition by reverse operation astroglial GABA transporter, induced Glu-Na+ symport. GABA, released from astr...

BACKGROUND The ATP-binding cassette (ABC) transporter gene superfamily is ubiquitous among extant organisms and prominently represented in plants. ABC transporters act to transport compounds across cellular membranes and are involved in a diverse range of biological processes. Thus, the applicability to biotechnology is vast, including cancer resistance in humans, drug resistance among vertebra...

The effects of 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] on gene expression and function were studied in Caco-2 cells. Microarray analyses, real-time quantitative polymerase chain reactions, and Western blotting were used to determine the mRNA and protein expression of transporters and enzymes after 1,25(OH)(2)D(3) or vehicle (0.1% ethanol) treatment for 1, 3, 6, and 10 days. The mRNA a...

The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal nerve terminals remain poorly understood. The dopamine transporters contain a C-terminal PDZ (PSD-95/Discs-large/ZO-1) domain-binding sequence believed to bind synaptic scaffolding proteins, but its functional significance is uncertain. Here...